vWF Multimers
Clinical Background:
The structure of von Willebrand factor in patients can be determined by electrophoresis of the plasma after treatment to break down the bonds in the molecule. This gives a 'ladder' effect with the ...
The structure of von Willebrand factor in patients can be determined by electrophoresis of the plasma after treatment to break down the bonds in the molecule. This gives a 'ladder' effect with the multimers being shown as bands from the highest weight to the lowest weight. Absence of particular bands is used to confirm the type of vWD and sub-type the Type 2 disorders
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
5.4mL
5.4mL
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Minimum Volume Paediatric:
2.6mL
2.6mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Fortnightly
Fortnightly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
No current scheme available
No current scheme available
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Reference Ranges:
Interpretation provided by Haematology medical staff.
Interpretation provided by Haematology medical staff.
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Other Info:
Analysis of vW multimer structure.
Performed as part of a vW Screen when considered clinically relevant.
Analysis of vW multimer structure.
Performed as part of a vW Screen when considered clinically relevant.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Routine Email:
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net