Newcastle Laboratories

Valproate, serum

Clinical Background:

Valproate has a different spectrum of anticonvulsant activity to the other commonly used anticonvulsants, and it is the drug of choice for the treatment of myoclonic seizures and generalised absenc...

Valproate has a different spectrum of anticonvulsant activity to the other commonly used anticonvulsants, and it is the drug of choice for the treatment of myoclonic seizures and generalised absence seizures because of its minimal sedative action and absence of CNS side effects.It is also effective in general and partial epilepsy and has been used in the prophylaxis of febrile convulsions.
Valproate is an effective option in the therapy of bipolar affective disorder.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1 mL

    1 mL

  • Minimum Volume Paediatric:

    0.5 mL

    0.5 mL

  • Special Requirement:

    Trough sample required

    Trough sample required

  • Sample Stability:

    Unseparated sample: 2 days
    Separated sample: 7 days at 4°C

    Unseparated sample: 2 days
    Separated sample: 7 days at 4°C

  • Interpretation:

    Monitoring therapy
    Pharmacokinetic studies indicate a poor relationship with pharmacodynamics.
    Most authorities agree routine monitoring is not necessary
    Monitoring is found useful when compliance ...

    Monitoring therapy
    Pharmacokinetic studies indicate a poor relationship with pharmacodynamics.
    Most authorities agree routine monitoring is not necessary
    Monitoring is found useful when compliance is an issue
    Little hard evidence for a therapeutic valproate range though 50 – 100mg/L is often quoted. It is clear that some patients are well controlled with concentrations well below 50mg/L and others may require well in excess of 100mg/L.
    Toxicity
    Important side effects include weight gain, paediatric hepatotoxicity and hyperammonaemia. There is also a possible teratogenic effect.

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  • Reference Ranges:

    Therapeutic Range 50 - 100 mg/L

    Therapeutic Range 50 - 100 mg/L

  • Other Info:

    Plasma- Lithium Heparin also acceptable

    Plasma- Lithium Heparin also acceptable

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

Availability:

Available 24/7
Site of analysis: RVI

Turn Around:

- Urgent sample: 1 hour

Done on a single site. Where urgent samples come from a different site, they will be done within 3 hours.

- Routine sample: 4 hours

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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