Newcastle Laboratories

TSH Receptor Antibodies

Clinical Background:

TRAbs are antibodies directed against the thyroid TSH receptor.

The clinical uses of its measurement are as follows:-

Diagnosis and monitoring of Graves Disease: Graves disease is caused by the pre...

TRAbs are antibodies directed against the thyroid TSH receptor.

The clinical uses of its measurement are as follows:-

Diagnosis and monitoring of Graves Disease: Graves disease is caused by the presence of TRAbs, which stimulate the TSH receptor leading to hyperthyroidism. Measurement of TRAbs is therefore useful in the differential diagnosis of hyperthyroidism. Monitoring TRAbs in patients with known Graves disease can also predict short-term relapses following a course of anti-thyroid drugs.


Prediction of the risk of thyrotoxicosis in the foetus or neonate: TRAbs may cross the placenta and potentially cause fetal and neonatal hyperthyroidism (or hypothyroidism in the case of blocking antibodies), which carries increased risk of neonatal morbidity and mortality if not recognised and treated.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-SST

    Serum-SST

  • Minimum Volume Adult:

    2 mL blood

    2 mL blood

  • Minimum Volume Paediatric:

    1 mL blood

    1 mL blood

  • Special Requirement:

    None noted

    None noted

  • Sample Stability:

    Unseparated: Same day

    Separated: 3 days at 4-8oC, 1 month at -20oC

    Unseparated: Same day

    Separated: 3 days at 4-8oC, 1 month at -20oC

  • Transport Requirements:

    Ambient

    Ambient

  • Interpretation:

    TRAB >1.8 IU/L is regarded as positive
    TRAB 1.0 to 1.8 IU/L is equivocal
    TRAB <1.0 IU/L is regarded as negative

    TRAB >1.8 IU/L is regarded as positive
    TRAB 1.0 to 1.8 IU/L is equivocal
    TRAB <1.0 IU/L is regarded as negative

  • Reference Ranges:

    Results of greater than 1.8 U/L are considered positive.

    Results of greater than 1.8 U/L are considered positive.

  • Factors Affecting Result:

    Gross haemolysis, lipaemia or icterus may interfere.

    Gross haemolysis, lipaemia or icterus may interfere.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

  • Routine Email:

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Endocrine Lab

    Endocrine Lab

  • Specialist Telephone:

    0191 282 4025

    0191 282 4025

Availability:

Available during full access hours
Assayed weekly
Site of analysis: RVI

Turn Around:

Within 2 weeks

Send To:

Department of Blood Sciences – RVI

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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