TSH Receptor Antibodies
Clinical Background:
TRAbs are antibodies directed against the thyroid TSH receptor.
The clinical uses of its measurement are as follows:-
Diagnosis and monitoring of Graves Disease: Graves disease is caused by the pre...
TRAbs are antibodies directed against the thyroid TSH receptor.
The clinical uses of its measurement are as follows:-
Diagnosis and monitoring of Graves Disease: Graves disease is caused by the presence of TRAbs, which stimulate the TSH receptor leading to hyperthyroidism. Measurement of TRAbs is therefore useful in the differential diagnosis of hyperthyroidism. Monitoring TRAbs in patients with known Graves disease can also predict short-term relapses following a course of anti-thyroid drugs.
Prediction of the risk of thyrotoxicosis in the foetus or neonate: TRAbs may cross the placenta and potentially cause fetal and neonatal hyperthyroidism (or hypothyroidism in the case of blocking antibodies), which carries increased risk of neonatal morbidity and mortality if not recognised and treated.
Test Details
-
Discipline:
Biochemistry
Biochemistry
-
Specimen Container Adult:
Serum-SST
Serum-SST
-
Specimen Container Paediatric:
Serum-SST
Serum-SST
-
Minimum Volume Adult:
2 mL blood
2 mL blood
-
Minimum Volume Paediatric:
1 mL blood
1 mL blood
-
Special Requirement:
None noted
None noted
-
Sample Stability:
Unseparated: Same day
Separated: 3 days at 4-8oC, 1 month at -20oC
Unseparated: Same day
Separated: 3 days at 4-8oC, 1 month at -20oC
-
Transport Requirements:
Ambient
Ambient
-
Interpretation:
TRAB >1.8 IU/L is regarded as positive
TRAB 1.0 to 1.8 IU/L is equivocal
TRAB <1.0 IU/L is regarded as negativeTRAB >1.8 IU/L is regarded as positive
TRAB 1.0 to 1.8 IU/L is equivocal
TRAB <1.0 IU/L is regarded as negative -
Reference Ranges:
Results of greater than 1.8 U/L are considered positive.
Results of greater than 1.8 U/L are considered positive.
-
Factors Affecting Result:
Gross haemolysis, lipaemia or icterus may interfere.
Gross haemolysis, lipaemia or icterus may interfere.
-
Routine Contact Name:
Duty Biochemist
-
Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
-
Routine Email:
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Endocrine Lab
Endocrine Lab
-
Specialist Telephone:
0191 282 4025
0191 282 4025