Trimethylamine / Trimethylamine-n-oxide
Clinical Background:
For the diagnosis of Trimethylaminuria (aka Fish Odour Syndrome)
For the diagnosis of Trimethylaminuria (aka Fish Odour Syndrome)
Test Details
-
Discipline:
Biochemistry
Biochemistry
-
Specimen Container Adult:
Urine - acidified
Urine - acidified
-
Specimen Container Paediatric:
Urine - acidified
Urine - acidified
-
Minimum Volume Adult:
20 mL
20 mL
-
Minimum Volume Paediatric:
20 mL
20 mL
-
Special Requirement:
Random urine must be acidified to pH <2 with 6M hydrochloric acid ASAP after arrival in the lab
Collect 24 hour urine in HCl containing container
Recommend patients have a 'choline load' the day bef...Read MoreRandom urine must be acidified to pH <2 with 6M hydrochloric acid ASAP after arrival in the lab
Collect 24 hour urine in HCl containing container
Recommend patients have a 'choline load' the day before their first urine collection - e.g. 2 meals containing 2 eggs + 400g beans - [50%less for children under 10] -
Sample Stability:
Freeze sample
Freeze sample
-
Transport Requirements:
Sample sent frozen
Sample sent frozen
-
Reference Ranges:
TMA: < 7.7 μmol/mmol creatinine
TMANO: < 119μmol/mmol creatinine
% N-oxidation: > 90-94%TMA: < 7.7 μmol/mmol creatinine
TMANO: < 119μmol/mmol creatinine
% N-oxidation: > 90-94% -
Other Info:
Dimethylglycine is no longer part of the profile. If required, it must be requested separately.
Dimethylglycine is no longer part of the profile. If required, it must be requested separately.
-
Routine Contact Name:
Duty Biochemist
-
Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
-
Routine Email:
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Metabolic Clinical Scientist
Metabolic Clinical Scientist
-
Specialist Telephone:
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
-
Specialist Email: