Thrombin Time
Clinical Background:
Test used to determine the time taken to form a clot in plasma after the addition of Thrombin. It is used in conjunction with the Protamine Time to detect the presence of Heparin in a sample (TT wi...
Test used to determine the time taken to form a clot in plasma after the addition of Thrombin. It is used in conjunction with the Protamine Time to detect the presence of Heparin in a sample (TT will be prolonged and Protamine Time will be normal). It can also be prolonged by Fibrinogen deficiency, dysfunction and fibrin degredation products. The Thrombin Time is particularly senstiive to the Direct Thrombin Inhibitor Dabigatran (Pradaxa) which will give very long Thrombin Times even at sub-therapeutic levels
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
24 hrs
24 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Continuous
Continuous
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
12 - 16 seconds.
12 - 16 seconds.
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Other Info:
Used in conjunction with a Reptilase Time to determine cause of prolonged APTT.
Used in conjunction with a Reptilase Time to determine cause of prolonged APTT.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
No
No
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net