Specific Microbial Antibodies
Clinical Background:
Specific Microbial Antibodies are used in the investigation of suspected immune deficiency. Levels pre and post immunisation are often more useful than isolated results. The investigation of immune...
Specific Microbial Antibodies are used in the investigation of suspected immune deficiency. Levels pre and post immunisation are often more useful than isolated results. The investigation of immune deficiency should be discussed with the immunology department (adult or paediatric) prior to requesting these tests. They are also used in the monitoring of asplenia. Specific antibodies should be checked annually and if pneumococcal levels fall below 35 mg/l or haemophilus influenzae type b below 1.5 mg/l re-immunisation is indicated. Levels of these antibodies may also be used in the assessment of the degree of protection in patients requiring re-immunisation, particularly where adverse reactions have occurred in the past. Under these circumstances protective levels are; pneumococcal antibody levels >20mg/l, tetanus antibody levels >0.1 IU/ml, Hib antibody levels >1.0 mg/l.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1 ml
1 ml
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Minimum Volume Paediatric:
1 ml
1 ml
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Special Requirement:
None
None
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Freq Analysis:
Monthly
Monthly
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Add On Test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net
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Quality Assurance:
UK NEQAS for Specific Microbial Antibodies
UK NEQAS for Specific Microbial Antibodies
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Interpretation:
None
None
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Reference Ranges:
Haemophilus Influenzae B (mg/L) 1.0 – 20 mg/L
Pneumococcal Capsular Polysaccharide (mg/L) 20 – 200 mg/L
Tetanus Toxoid (IU/ml) ...
Read MoreHaemophilus Influenzae B (mg/L) 1.0 – 20 mg/L
Pneumococcal Capsular Polysaccharide (mg/L) 20 – 200 mg/L
Tetanus Toxoid (IU/ml) 0.1 – 10 IU/ml
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Other Info:
Specific antibodies are available to Pneumococcus, Tetanus and Haemophilus influenzae type b. Interpretation of results depends on prior exposure or immunisation status.
Specific antibodies are available to Pneumococcus, Tetanus and Haemophilus influenzae type b. Interpretation of results depends on prior exposure or immunisation status.
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: