Scl-70 Antibodies
Clinical Background:
Scl-70 antibodies are found in 20-40% of patients with diffuse cutaneous systemic sclerosis. Patients with these antibodies are said to develop particularly severe skin disease, musculoskeletal dis...
Scl-70 antibodies are found in 20-40% of patients with diffuse cutaneous systemic sclerosis. Patients with these antibodies are said to develop particularly severe skin disease, musculoskeletal disease and cardiopulmonary disease.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1 ml
1 ml
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Minimum Volume Paediatric:
0.5 ml
0.5 ml
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Special Requirement:
None
None
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Freq Analysis:
Daily
Daily
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Add On Test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net
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Quality Assurance:
UK NEQAS for Antibodies to Nuclear and Related Antigens
UK NEQAS for Antibodies to Nuclear and Related Antigens
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Interpretation:
None
None
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Reference Ranges:
Normal Range: Negative
Normal Range: Negative
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Other Info:
Scl-70 antibodies are detected as part of the ANA and Related antibodies assay (BioPlex) and are reported as Negative or Positive. Samples giving results in an internally defined borderline range a...
Read MoreScl-70 antibodies are detected as part of the ANA and Related antibodies assay (BioPlex) and are reported as Negative or Positive. Samples giving results in an internally defined borderline range are retested using another method (Immunoblotting) to give a definitive result and this is reported as Negative, Borderline, Positive, or Strongly positive.
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Routine Contact Name:
Jason Sillitoe
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: