Newcastle Laboratories

Salicylate, serum

Clinical Background:

Aspirin is an analgesic, antipyretic, anti-inflammatory drug contained in a large number of preparations. Aspirin is rapidly hydrolyzed by the liver to the pharmacologically active intermediate, sa...

Aspirin is an analgesic, antipyretic, anti-inflammatory drug contained in a large number of preparations. Aspirin is rapidly hydrolyzed by the liver to the pharmacologically active intermediate, salicylate. Salicylate measurement in serum is used to diagnose and treat salicylate overdose and to monitor salicylate levels to ensure appropriate therapy. Salicylate overdosage can cause acid-base disturbances such as compensated respiratory alkalosis, metabolic acidosis with increased anion gap (severe toxicity) and hypokalaemia.

Read More

Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Specimen Container Paediatric:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Minimum Volume Adult:

    1 mL blood

    1 mL blood

  • Minimum Volume Paediatric:

    0.5 mL blood

    0.5 mL blood

  • Sample Stability:

    Before separation: unknown
    After separation:
    at +15° to +25°C: 7 day
    at +2° to +8°C: 14 days
    at -20°C: 6 months

    Before separation: unknown
    After separation:
    at +15° to +25°C: 7 day
    at +2° to +8°C: 14 days
    at -20°C: 6 months

  • Quality Assurance:

    WEQAS

    WEQAS

  • Interpretation:

    Severity of poisoning cannot be assessed from plasma salicylate concentrations alone but salicylate intoxication is usually associated with plasma concentrations greater than 350 mg/L.

    Measurement...

    Severity of poisoning cannot be assessed from plasma salicylate concentrations alone but salicylate intoxication is usually associated with plasma concentrations greater than 350 mg/L.

    Measurement of serum salicylate is not intended for use with low-dose aspirin therapy. Most patients on low daily doses of aspirin for cardiovascular prophylaxis will have serum concentrations near or below the lower limit of the analytical range.

    Read More
  • Reference Ranges:

    Therapeutic Ranges:
    Analgesia, antipyresis: 30 - 100 mg/L
    Anti-inflammatory: 150 - 300 mg/L

    Therapeutic Ranges:
    Analgesia, antipyresis: 30 - 100 mg/L
    Anti-inflammatory: 150 - 300 mg/L

  • Other Info:

    Lithium heparin plasma samples also acceptable

    Lithium heparin plasma samples also acceptable

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    0191 282 9719

    0191 282 9719

  • Routine Email:

Availability:

24/7, analysed at RVI

Turn Around:

Urgent: within 1 hour
Non-urgent: within 1 day

View all tests