Salicylate, serum
Clinical Background:
Aspirin is an analgesic, antipyretic, anti-inflammatory drug contained in a large number of preparations. Aspirin is rapidly hydrolyzed by the liver to the pharmacologically active intermediate, sa...
Aspirin is an analgesic, antipyretic, anti-inflammatory drug contained in a large number of preparations. Aspirin is rapidly hydrolyzed by the liver to the pharmacologically active intermediate, salicylate. Salicylate measurement in serum is used to diagnose and treat salicylate overdose and to monitor salicylate levels to ensure appropriate therapy. Salicylate overdosage can cause acid-base disturbances such as compensated respiratory alkalosis, metabolic acidosis with increased anion gap (severe toxicity) and hypokalaemia.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Specimen Container Paediatric:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Minimum Volume Adult:
1 mL blood
1 mL blood
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Minimum Volume Paediatric:
0.5 mL blood
0.5 mL blood
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Sample Stability:
Before separation: unknown
After separation:
at +15° to +25°C: 7 day
at +2° to +8°C: 14 days
at -20°C: 6 monthsBefore separation: unknown
After separation:
at +15° to +25°C: 7 day
at +2° to +8°C: 14 days
at -20°C: 6 months -
Quality Assurance:
WEQAS
WEQAS
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Interpretation:
Severity of poisoning cannot be assessed from plasma salicylate concentrations alone but salicylate intoxication is usually associated with plasma concentrations greater than 350 mg/L.
Measurement...Read MoreSeverity of poisoning cannot be assessed from plasma salicylate concentrations alone but salicylate intoxication is usually associated with plasma concentrations greater than 350 mg/L.
Measurement of serum salicylate is not intended for use with low-dose aspirin therapy. Most patients on low daily doses of aspirin for cardiovascular prophylaxis will have serum concentrations near or below the lower limit of the analytical range. -
Reference Ranges:
Therapeutic Ranges:
Analgesia, antipyresis: 30 - 100 mg/L
Anti-inflammatory: 150 - 300 mg/LTherapeutic Ranges:
Analgesia, antipyresis: 30 - 100 mg/L
Anti-inflammatory: 150 - 300 mg/L -
Other Info:
Lithium heparin plasma samples also acceptable
Lithium heparin plasma samples also acceptable
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
0191 282 9719
0191 282 9719
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Routine Email: