Ristocetin Co-factor
Clinical Background:
The 'gold standard' for assessing von Willebrand Factor functional activity. Normal Ristocetin Co-Factor activity requires a normal level of full length plasma von Willebrand Multimers. The assay i...
The 'gold standard' for assessing von Willebrand Factor functional activity. Normal Ristocetin Co-Factor activity requires a normal level of full length plasma von Willebrand Multimers. The assay is especially important in determining the response of type 2 vWD patients to treatment, vW Antigen may rise in type 2 patients without a rise in function, with the potential for bleeding problems if only the antigen was used to determine response.
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
5.4mL
5.4mL
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Minimum Volume Paediatric:
2.6mL
2.6mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
40 - 150 IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
...Read More40 - 150 IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
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Other Info:
Used in the diagnosis of von Willebrand Disease.
Performed as part of a vW Screen.
Used in the diagnosis of von Willebrand Disease.
Performed as part of a vW Screen.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net