Newcastle Laboratories

Rheumatoid Factor

Clinical Background:

Rheumatoid Factors occur in a wide variety of conditions including viral infections, chronic bacterial infections, myeloma, lymphoma and connective tissue disease. Healthy elderly people may also h...

Rheumatoid Factors occur in a wide variety of conditions including viral infections, chronic bacterial infections, myeloma, lymphoma and connective tissue disease. Healthy elderly people may also have a positive Rheumatoid Factor. In Rheumatoid Arthritis the Rheumatoid Factor may be positive or negative, high titres are seen in progressive and extra-articular disease.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Specimen Container Paediatric:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Minimum Volume Adult:

    1 ml

    1 ml

  • Minimum Volume Paediatric:

    1 ml

    1 ml

  • Sample Stability:

    Unseparated sample: Unknown
    Separated sample: 24 hours at 15-25°C, 8 days at 2-8°C, 3 months at -20°C.

    Unseparated sample: Unknown
    Separated sample: 24 hours at 15-25°C, 8 days at 2-8°C, 3 months at -20°C.

  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address

    nuth.autoimmunity@nhs.net

     

    All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address

    nuth.autoimmunity@nhs.net

     

  • Quality Assurance:

    UK NEQAS for General Autoimmune Serology

    UK NEQAS for General Autoimmune Serology

  • Interpretation:

    In Rheumatoid Arthritis the Rheumatoid Factor may be positive or negative, high titres are seen in progressive and extra-articular disease.

    In Rheumatoid Arthritis the Rheumatoid Factor may be positive or negative, high titres are seen in progressive and extra-articular disease.

  • Reference Ranges:

    Normal Range: 0 - 19 IU/ml

    Normal Range: 0 - 19 IU/ml

  • Other Info:

    Plasma- Lithium Heparin also acceptable. Serial monitoring of Rheumatoid Factor is not recommended, as there is not a useful correlation with disease activity.

    Plasma- Lithium Heparin also acceptable. Serial monitoring of Rheumatoid Factor is not recommended, as there is not a useful correlation with disease activity.

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

  • Specialist Email:

    nuth.autoimmunity@nhs.net

    nuth.autoimmunity@nhs.net

Availability:

The Rheumatoid Factor assay is run on a daily basis, Monday to Friday 08:30 to 17:00.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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