PNH screen
Clinical Background:
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare, life threatening, acquired haematopoetic stem cell disorder that affects all blood cell lineages. Somatic mutation of the X-linked phosphatidyl...
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare, life threatening, acquired haematopoetic stem cell disorder that affects all blood cell lineages. Somatic mutation of the X-linked phosphatidylinositol glycan complementation Class A (PIG-A) gene leads to partial or absolute deficiency of all proteins linked to the cell membrane by a glycol-phosphatidylinositol (GPI) anchor.
Test Details
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Discipline:
Flowcytometry
Flowcytometry
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Specimen Container Adult:
Purple top EDTA
Purple top EDTA
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Specimen Container Paediatric:
pink top paediatric EDTA
pink top paediatric EDTA
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Minimum Volume Adult:
0.5ml
0.5ml
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Minimum Volume Paediatric:
0.5ml
0.5ml
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Sample Stability:
If kept at 4 degrees samples can be tested up to 3 days old
If kept at 4 degrees samples can be tested up to 3 days old
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Transport Requirements:
Ambient
Ambient
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Freq Analysis:
6 monthly unless clinically indicated.
6 monthly unless clinically indicated.
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Add On Test:
Use the contact details below to discuss if an add-on is required
Use the contact details below to discuss if an add-on is required
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Quality Assurance:
UKNEQAS PNH
UKNEQAS PNH
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Reference Ranges:
PNH clones should not be present
Sensitivity for neutrophils and red blood cells is 0.01%
PNH clones should not be present
Sensitivity for neutrophils and red blood cells is 0.01%
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Other Info:
A neutrophil count is required.
A neutrophil count is required.
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Routine Contact Name:
Flow Cytometry Lab
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Routine Telephone:
0191 282 5078
0191 282 5078
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Routine Email:
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Specialist Email:
Use the contact details below to discuss if an add-on is required
Use the contact details below to discuss if an add-on is required