Platelet Aggregation
Clinical Background:
Platelets are responsible for forming the primary haemostatic plug during coagluation and normal platelet function is crucial to this. Platelet function is determined by adding a panel of reagents ...
Platelets are responsible for forming the primary haemostatic plug during coagluation and normal platelet function is crucial to this. Platelet function is determined by adding a panel of reagents (agonists) to a suspension of test platelets and measuring the aggregation response of the platelets to the stumuli. The pattern of aggregation seen with the different agonists allows an examination of several different metabolic pathways in the platelet that are required for normal function
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate x 4.
Light blue - sodium citrate x 4.
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Specimen Container Paediatric:
Light blue - sodium citrate x 4.
Light blue - sodium citrate x 4.
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Minimum Volume Adult:
10.8mL
10.8mL
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Minimum Volume Paediatric:
5.4mL
5.4mL
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Special Requirement:
Tubes must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tubes must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
2 hrs
2 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
On request
On request
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation (Pilot scheme)
UK NEQAS Blood Coagulation (Pilot scheme)
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Reference Ranges:
Agonists used include:
Arachidonic acid
ADP
Collagen
Epinephrine
Ristocetin
Results will be interpreted by Haematology medical staff.
Agonists used include:
Arachidonic acid
ADP
Collagen
Epinephrine
Ristocetin
Results will be interpreted by Haematology medical staff.
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Factors Affecting Result:
Time limited test, tests must be completed within 4 hours of venepunture
Time limited test, tests must be completed within 4 hours of venepunture
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Other Info:
A measure of platelet function with known agonists.
A measure of platelet function with known agonists.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net