Newcastle Laboratories

Oxalate, urine

Clinical Background:

A raised urinary oxalate can result in the formation of renal stones which are predominantly composed of the sparingly soluble salt of calcium oxalate. Causes of hyperoxaluria include ingestion of ...

A raised urinary oxalate can result in the formation of renal stones which are predominantly composed of the sparingly soluble salt of calcium oxalate. Causes of hyperoxaluria include ingestion of oxalate rich foods, increased GI absorption of oxalate when there is severe fat malabsorption and rarely inherited disorders of metabolism such as primary oxaluria. An oxalate is commonly measured in urine in the investigation of renal calculi.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    24 hrs urine collection (plain bottle)

    24 hrs urine collection (plain bottle)

  • Specimen Container Paediatric:

    Random urine sample (plain container)

    Random urine sample (plain container)

  • Minimum Volume Adult:

    2 mL 

    2 mL 

  • Minimum Volume Paediatric:

    1 mL 

    1 mL 

  • Special Requirement:

    For external users: samples must be acidified to pH<2.

    Patient should refrain from excess vitamin C for at least 48h prior to collection.

    For external users: samples must be acidified to pH<2.

    Patient should refrain from excess vitamin C for at least 48h prior to collection.

  • Interpretation:

    An increased excretion of oxalate can be attributed to increases in:
    • Ingestion of oxalate rich foods, e.g. rhubarb.
    • Formation of oxalate due to metabolic defects such as in primary hyperoxaluri...

    An increased excretion of oxalate can be attributed to increases in:
    • Ingestion of oxalate rich foods, e.g. rhubarb.
    • Formation of oxalate due to metabolic defects such as in primary hyperoxaluria
    • Absorption of oxalate in a number of gastrointestinal disorders that produce severe fat malabsorption including patients with inflammatory bowel disease, ileal resection, and pancreatic insufficiency.

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  • Reference Ranges:

    24h urine (mmol/24h)

    Adult male: 0.08 – 0.49 mmol/24 hrs
    Adult female: 0.04 – 0.32 mmol/24 hrs
    Children: 0.14-0.42 mmol/24 hrs


    Random urine (mmol/mmol creatinine)

    <1 yr: 0.015 – 0.260

    1-4 yrs: 0.011...

    24h urine (mmol/24h)

    Adult male: 0.08 – 0.49 mmol/24 hrs
    Adult female: 0.04 – 0.32 mmol/24 hrs
    Children: 0.14-0.42 mmol/24 hrs


    Random urine (mmol/mmol creatinine)

    <1 yr: 0.015 – 0.260

    1-4 yrs: 0.011-0.120

    5-11 yrs: 0.006-0.150

    >12 yrs: 0.002-0.083

     

    <1 yr: 0.015 – 0.260

    1-4 yrs: 0.011-0.120

    5-11 yrs: 0.006-0.150

    >12 yrs: 0.002-0.083

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  • Factors Affecting Result:

    A diet rich in rhubarb will increase oxalate secretion

    A diet rich in rhubarb will increase oxalate secretion

  • Routine Contact Name:

    Duty biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

Availability:

Sample sent to an external laboratory for analysis

Turn Around:

3 weeks

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