Newcastle Laboratories

Myeloperoxidase Antibodies

Clinical Background:

Myeloperoxidase (MPO) antibodies are part of the first-line testing protocol for small vessel vasculitis alongside Proteinase 3 (PR3). Positive MPO antibodies point towards microscopic polyangiitis...

Myeloperoxidase (MPO) antibodies are part of the first-line testing protocol for small vessel vasculitis alongside Proteinase 3 (PR3). Positive MPO antibodies point towards microscopic polyangiitis (MPA).

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1 ml

    1 ml

  • Minimum Volume Paediatric:

    1 ml

    1 ml

  • Special Requirement:

    None

    None

  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on : 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net

    All urgent add ons via telephone on : 0191 2821890, and must be confirmed via email to nuth.autoimmunity@nhs.net

  • Quality Assurance:

    UK NEQAS for Autoimmune Serology ANCA and GBM

    UK NEQAS for Autoimmune Serology ANCA and GBM

  • Interpretation:

    Antibodies to MPO are not specific and may be detected in a range of vasculitic conditions.

    Antibodies to MPO are not specific and may be detected in a range of vasculitic conditions.

  • Reference Ranges:

    Normal Range: 0 - 0.9 Antibody Index (AI)

    Normal Range: 0 - 0.9 Antibody Index (AI)

  • Other Info:

    Reported as a number between 0.2 and 8.0 AI

    Reported as a number between 0.2 and 8.0 AI

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 2821890

    0191 2821890

  • Routine Email:

Availability:

MPO antibodies are detected by BioPlex 2200 multiplex analyser and are run on a daily basis.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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