Newcastle Laboratories

Lupus Anticoagulant

Clinical Background:

The so-called Lupus Anticoagulant (LA) is an auto-immune antibody found in the plasma/serum of some patients with Anti-Phospholipid Syndrome (APS) and a range of other situations. The anti-body is ...

The so-called Lupus Anticoagulant (LA) is an auto-immune antibody found in the plasma/serum of some patients with Anti-Phospholipid Syndrome (APS) and a range of other situations. The anti-body is an anti-protein antibody and may occur transiently after a period of ill health or be persistant in APS. The antibody may be discovered by chance on pre-op screeing tests - the antibody will in most cases cause a prolongation of the APTT. The test involves the use of two reagents, prepared from snake venom, phospholipid and calcium, with results being expressed as a ratio of screen/confirm. There is an association with increased risk of thrombosis in subjects with APS, this risk is increasingly significant if the subject is also postive for an Anti-B2Gp1 antibody. This test is part of the Thrombophilia Screen and is also performed when investigating a prolonged APTT

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    2.7mL

    2.7mL

  • Minimum Volume Paediatric:

    1.3mL

    1.3mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    4 hrs

    4 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    Continuous

    Continuous

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nh...

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    Normal <1.2

    Normal <1.2

  • Other Info:

    Assay to indicate presence of a lupus anticoagulant.

    Assay to indicate presence of a lupus anticoagulant.

  • Routine Contact Name:

    Peter Strong

  • Routine Telephone:

    0191 282 0332

    0191 282 0332

  • Routine Email:

    p.strong@nhs.net

  • Specialist Test:

    No

    No

  • Specialist Contact Name:

    Haematology/Haemostasis Health care Scientist

    Haematology/Haemostasis Health care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

Available during routine hours, Monday to Friday.

Turn Around:

Usually within 3 days.

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