Newcastle Laboratories

LH, serum

Clinical Background:

Luteinising hormone (LH) is a glycoprotein produced by the basophilic cells of the anterior pituitary under the control of hypothalamic gonadotropin releasing hormone. LH in females causes ovulatio...

Luteinising hormone (LH) is a glycoprotein produced by the basophilic cells of the anterior pituitary under the control of hypothalamic gonadotropin releasing hormone. LH in females causes ovulation and steroid (oestrogen and progesterone) production by the corpus luteum. In the male, LH stimulates the interstitial cells (Leydig cells) to produce androgens and oestrogens. Circulating LH is regulated via steroid hormones exerting negative feedback on the hypothalamus. The clinical utility of LH determination (and that of FSH) is in the investigation of function of the hypothalamic-pituitary-gonadal axis.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum - SST

    Serum - SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1 mL blood

    1 mL blood

  • Minimum Volume Paediatric:

    1 mL blood

    1 mL blood

  • Sample Stability:

    Unseparated sample: 3 days at 15-25oC

    Separated sample: 7 days at 4-8°C, 6 months at -20°C

    Unseparated sample: 3 days at 15-25oC

    Separated sample: 7 days at 4-8°C, 6 months at -20°C

  • Transport Requirements:

    Ambient

    Ambient

  • Interpretation:

    Elevated LH concentrations are associated with primary gonadal failure. Low LH concentrations may be associated with hypogonadotrophic hypogonadism (i.e. GnRH deficiency) or due to suppression of G...

    Elevated LH concentrations are associated with primary gonadal failure. Low LH concentrations may be associated with hypogonadotrophic hypogonadism (i.e. GnRH deficiency) or due to suppression of GnRH secretion due to high concentrations of testosterone in men (e.g. in testosterone replacement therapy) or oestrogens in women (e.g. due to exogenous oestrogens or pregnancy).

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  • Reference Ranges:

    Male: 1.7 – 8.6 IU/L

     

    Female:

    Follicular: 2.4 – 12.6 IU/L

    Luteal: 1.0 – 11.4 IU/L

    Ovulation: 14.0 – 95.6 IU/L

    Postmenopausal: 7.7 – 58.5 IU/L

    Male: 1.7 – 8.6 IU/L

     

    Female:

    Follicular: 2.4 – 12.6 IU/L

    Luteal: 1.0 – 11.4 IU/L

    Ovulation: 14.0 – 95.6 IU/L

    Postmenopausal: 7.7 – 58.5 IU/L

  • Factors Affecting Result:

    Heterophilic antibodies can interfere with immunoassays.

    Heterophilic antibodies can interfere with immunoassays.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

  • Routine Email:

Availability:

Available 24/7
Site of analysis: RVI

Turn Around:

Within 2 full access days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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