LH, serum
Clinical Background:
Luteinising hormone (LH) is a glycoprotein produced by the basophilic cells of the anterior pituitary under the control of hypothalamic gonadotropin releasing hormone. LH in females causes ovulatio...
Luteinising hormone (LH) is a glycoprotein produced by the basophilic cells of the anterior pituitary under the control of hypothalamic gonadotropin releasing hormone. LH in females causes ovulation and steroid (oestrogen and progesterone) production by the corpus luteum. In the male, LH stimulates the interstitial cells (Leydig cells) to produce androgens and oestrogens. Circulating LH is regulated via steroid hormones exerting negative feedback on the hypothalamus. The clinical utility of LH determination (and that of FSH) is in the investigation of function of the hypothalamic-pituitary-gonadal axis.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Specimen Container Paediatric:
serum (SST or plain tube)
serum (SST or plain tube)
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Minimum Volume Adult:
1 mL blood
1 mL blood
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Minimum Volume Paediatric:
0.5 mL
0.5 mL
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Sample Stability:
Unseparated sample: 7 days
Separated sample: 3 days at 15-25°C, 14 days at 2-8°C, 6 months at -20°CUnseparated sample: 7 days
Separated sample: 3 days at 15-25°C, 14 days at 2-8°C, 6 months at -20°C -
Transport Requirements:
Ambient
Ambient
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Interpretation:
Elevated LH concentrations are associated with primary gonadal failure. Low LH concentrations may be associated with hypogonadotrophic hypogonadism (i.e. GnRH deficiency) or due to suppression of G...
Read MoreElevated LH concentrations are associated with primary gonadal failure. Low LH concentrations may be associated with hypogonadotrophic hypogonadism (i.e. GnRH deficiency) or due to suppression of GnRH secretion due to high concentrations of testosterone in men (e.g. in testosterone replacement therapy) or oestrogens in women (e.g. due to exogenous oestrogens or pregnancy).
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Reference Ranges:
Male: 1.7 – 8.6 IU/L
Female:
Follicular: 2.4 – 12.6 IU/L
Luteal: 1.0 – 11.4 IU/L
Ovulation: 14.0 – 95.6 IU/L
Postmenopausal: 7.7 – 58.5 IU/L
Male: 1.7 – 8.6 IU/L
Female:
Follicular: 2.4 – 12.6 IU/L
Luteal: 1.0 – 11.4 IU/L
Ovulation: 14.0 – 95.6 IU/L
Postmenopausal: 7.7 – 58.5 IU/L
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email: