LDH (Lactate dehydrogenase), serum
Clinical Background:
Lactate dehydrogenase (LDH) is a cytoplasmic enzyme present in all cells of the body with the highest concentrations in heart, liver, muscle, kidney, lung, and erythrocytes. As the LDH concentratio...
Lactate dehydrogenase (LDH) is a cytoplasmic enzyme present in all cells of the body with the highest concentrations in heart, liver, muscle, kidney, lung, and erythrocytes. As the LDH concentration in tissues is about 500 times higher than that in plasma, damage of even a small amount of tissue can lead to a significant increase in activity in serum. As a consequence serum LDH concentrations can be elevated in a number of clinical conditions. The total LDH measurable in serum consists of 5 isoenzymes, LD-1 to LD-5.
LDH is often used in monitoring changes in tumor burden after chemotherapy, although, lactate dehydrogenase elevations in patients with cancer are too erratic to be of use in the diagnosis of cancer.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Specimen Container Paediatric:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Minimum Volume Adult:
1 mL blood
1 mL blood
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Minimum Volume Paediatric:
0.5 mL blood
0.5 mL blood
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Sample Stability:
Unseparated sample: day of collection
Separated sample: 7 days at 15-25°C, 4 days at 2-8°C, 6 weeks at -20°CUnseparated sample: day of collection
Separated sample: 7 days at 15-25°C, 4 days at 2-8°C, 6 weeks at -20°C -
Reference Ranges:
0 - 1 month: 125 – 765 IU/L
1 montn - 1 year: 170 – 450 IU/L
1 - 2 years: 155 – 395 IU/L
2 - 15 years: 120 – 300 IU/L
15 years and over: 135 – 225 IU/L
0 - 1 month: 125 – 765 IU/L
1 montn - 1 year: 170 – 450 IU/L
1 - 2 years: 155 – 395 IU/L
2 - 15 years: 120 – 300 IU/L
15 years and over: 135 – 225 IU/L
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719Freeman: 0191 244 8889
RVI: 0191 282 9719 -
Routine Email: