Newcastle Laboratories

LDH (Lactate dehydrogenase), fluid

Clinical Background:

The serous body cavities contain a small amount of fluid that is an ultrafiltrate of plasma. When production and resorption of this ultrafiltrate are not balanced, fluid may accumulate, resulting i...

The serous body cavities contain a small amount of fluid that is an ultrafiltrate of plasma. When production and resorption of this ultrafiltrate are not balanced, fluid may accumulate, resulting in an effusion. Effusions may be classified as transudates or exudates. Transudates are usually bilateral and arise from either increased capillary hydrostatic pressure or decreased oncotic pressure secondary to congestive heart failure, fluid overload, cirrhosis or hypoalbuminemia. Exudates are usually unilateral and result from increased capillary permeability or decreased lymphatic resorption associated with infection, connective tissue disease, pancreatitis or cancer.Fluid LDH can, using Light's criteria, be used to differentiate between transudates and exudates.

Read More

Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Fluid in plain tube

    Fluid in plain tube

  • Specimen Container Paediatric:

    Fluid in plain tube

    Fluid in plain tube

  • Minimum Volume Adult:

    1 mL fluid

    1 mL fluid

  • Minimum Volume Paediatric:

    1 mL fluid

    1 mL fluid

  • Special Requirement:

    Samples which are too viscous and/or contain particulate matter after centrifugation are unsuitable for analysis.

    Samples which are too viscous and/or contain particulate matter after centrifugation are unsuitable for analysis.

  • Add On Test:

    Up to 24 hours. Samples after this time period are stored refrigerated and are therefore unsuitable for LDH measurement.

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via...

    Up to 24 hours. Samples after this time period are stored refrigerated and are therefore unsuitable for LDH measurement.

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

    Read More
  • Interpretation:

    Exudative effusions
    See the list below:

    Abdominal fluid: Abscess in tissues near lung, ascites, Meigs syndrome, pancreatitis
    Connective-tissue disease: Churg-Strauss disease, lupus, rheumatoid arthri...

    Exudative effusions
    See the list below:

    Abdominal fluid: Abscess in tissues near lung, ascites, Meigs syndrome, pancreatitis
    Connective-tissue disease: Churg-Strauss disease, lupus, rheumatoid arthritis, Wegener granulomatosis
    Endocrine: Hypothyroidism, ovarian hyperstimulation
    Iatrogenic: Drug-induced, esophageal perforation, feeding tube in lung
    Infectious: Abscess in tissues near lung, bacterial pneumonia, fungal disease, parasites, tuberculosis
    Inflammatory: Acute respiratory distress syndrome (ARDS), asbestosis, pancreatitis, radiation, sarcoidosis, uremia
    Lymphatic abnormalities: Chylothorax, malignancy, lymphangiectasia
    Malignancy: Carcinoma, lymphoma, leukemia, mesothelioma, paraproteinemia

    Read More
  • Reference Ranges:

    Fluid is exudate if one of the following Light’s criteria is present:
    Fluid protein/serum protein ratio greater than 0.5
    Fluid lactate dehydrogenase (LDH)/serum LDH ratio greater than 0.6
    Fluid LDH le...

    Fluid is exudate if one of the following Light’s criteria is present:
    Fluid protein/serum protein ratio greater than 0.5
    Fluid lactate dehydrogenase (LDH)/serum LDH ratio greater than 0.6
    Fluid LDH level greater than two-thirds the upper limit of the laboratory's reference range of serum LDH

    Read More
  • Factors Affecting Result:

    The presence of red blood cells and haemolysis.

    The presence of red blood cells and haemolysis.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889 
    RVI: 0191 282 9719

    Freeman: 0191 244 8889 
    RVI: 0191 282 9719

  • Routine Email:

Availability:

All times

All sites

Turn Around:

Batched assay, analysed twice per day.

View all tests