Newcastle Laboratories

Intrinsic Factor Antibody

Clinical Background:

Pernicious anaemia is caused due to a lack of Intrinsic Factor (IF) which is a protein produced by gastric parietal cells. IF is required for absorption of vitamin B12 from the diet. This condition...

Pernicious anaemia is caused due to a lack of Intrinsic Factor (IF) which is a protein produced by gastric parietal cells. IF is required for absorption of vitamin B12 from the diet. This condition is primarily caused when the body's immune system targets its own tissues and develops antibodies directed against the parietal cells and/or IF. The antibodies can damage the parietal cells and disrupt IF production or prevent IF from carrying out its function.

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Serum - SST or Serum-Plain tube

    Serum - SST or Serum-Plain tube

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1.0mL

    1.0mL

  • Minimum Volume Paediatric:

    0.5mL

    0.5mL

  • Special Requirement:

    Ensure adequate mixing.

     

    Ensure adequate mixing.

     

  • Sample Stability:

    Refrigerated at 2 – 8 °C - 5 days

    Unseperated non-refrigerated - 24 hrs

    Frozen - 6 Months

    Refrigerated at 2 – 8 °C - 5 days

    Unseperated non-refrigerated - 24 hrs

    Frozen - 6 Months

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    Batch assay

    Batch assay

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nh...

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS Haematinics

    UK NEQAS Haematinics

  • Other Info:

    Test to indicate the presence of an intrinsic factor antibody (IFA).

    Test to indicate the presence of an intrinsic factor antibody (IFA).

  • Routine Contact Name:

    Special Lab Freeman

  • Routine Telephone:

    0191 223 1780

    0191 223 1780

  • Routine Email:

    Joanne.hall8@nhs.net

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health Care Scientist

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    Haematology/Haemostasis Health Care Scientist

    /p>

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

All testing performed at Freeman Haematology laboratory and available during routine hours, Monday to Friday. Testing is usually performed on a weekly basis, depending on batch size availability.

Turn Around:

Usually within 7 days.

Send To:

Department of Blood Sciences

Freeman Hospital
Freeman Road
Newcastle upon Tyne
NE7 7DN

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