Intrinsic Factor Antibody
Clinical Background:
Pernicious anaemia is caused due to a lack of Intrinsic Factor (IF) which is a protein produced by gastric parietal cells. IF is required for absorption of vitamin B12 from the diet. This condition...
Pernicious anaemia is caused due to a lack of Intrinsic Factor (IF) which is a protein produced by gastric parietal cells. IF is required for absorption of vitamin B12 from the diet. This condition is primarily caused when the body's immune system targets its own tissues and develops antibodies directed against the parietal cells and/or IF. The antibodies can damage the parietal cells and disrupt IF production or prevent IF from carrying out its function.
Test Details
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Discipline:
Autoimmunology
Autoimmunology
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Specimen Container Adult:
Serum - SST or Serum-Plain tube
Serum - SST or Serum-Plain tube
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1.0mL
1.0mL
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Minimum Volume Paediatric:
0.5mL
0.5mL
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Special Requirement:
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Sample Stability:
Refrigerated at 2 – 8 °C - 5 days
Unseperated non-refrigerated - 24 hrs
Frozen - 6 Months
Refrigerated at 2 – 8 °C - 5 days
Unseperated non-refrigerated - 24 hrs
Frozen - 6 Months
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Batch assay
Batch assay
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Add On Test:
All urgent add ons via telephone on 0191 2821890 and must be confirmed via email to the appropriate email address.
Nuth.autoimmunity@nhs.netAll urgent add ons via telephone on 0191 2821890 and must be confirmed via email to the appropriate email address.
Nuth.autoimmunity@nhs.net -
Quality Assurance:
UK NEQAS Haematinics
UK NEQAS Haematinics
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Other Info:
Test to indicate the presence of an intrinsic factor antibody (IFA).
Test to indicate the presence of an intrinsic factor antibody (IFA).
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Routine Contact Name:
Jason Sillitoe
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Routine Telephone:
0191 2821890
0191 2821890
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Routine Email:
j.sillitoe@nhs.net
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Specialist Test:
Yes
Yes