INR Post DOAC-Remove
Clinical Background:
INR is the accepted method for controlling Vitamin K antagonist anticoagulant therapy (primarily Warfarin). The patients Prothrombin Time (PT) is divided by the laboratory Mean Normal Prothrombin T...
INR is the accepted method for controlling Vitamin K antagonist anticoagulant therapy (primarily Warfarin). The patients Prothrombin Time (PT) is divided by the laboratory Mean Normal Prothrombin Time (MNPT) and the resulting ratio is then raised to the power of the ISI, to convert results to a common WHO standard. However, for patients on Warfarin and a direct oral anticoagulant (DOAC), such as Bivalirudin, patient plasma must be pre-treated with DOAC-RemoveTM to remove the DOAC before an INR can be performed to obtain reliable results.
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue – sodium citrate
Light blue – sodium citrate
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Specimen Container Paediatric:
Light blue – sodium citrate
Light blue – sodium citrate
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Minimum Volume Adult:
2.7ml
2.7ml
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Minimum Volume Paediatric:
1.3ml
1.3ml
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
24 Hours
24 Hours
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
1.5 – 4.0. Dependent upon specific target value for patient.
1.5 – 4.0. Dependent upon specific target value for patient.
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Other Info:
To monitor warfarin like anticoagulants when patient also on DOAC
To monitor warfarin like anticoagulants when patient also on DOAC
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Routine Email:
Emily.lloyd21@nhs.net
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net