Inhibitor Titre
Clinical Background:
An Inhibitor Titre quantifies the activity of a specific coagulation factor inhibitor found in plasma. A standard method is used, with patients plasma being incubated with a normal plasma and the a...
An Inhibitor Titre quantifies the activity of a specific coagulation factor inhibitor found in plasma. A standard method is used, with patients plasma being incubated with a normal plasma and the amount of coagulation factor inhibited in a set time measured. This is converted to an inhibitor activity (titre) and expressed in Bethesda Units (BU). Patients with inhibitors are divided into Low Responders (Titre 5 BU), this classification may influence the treatment choice for the patient
Test Details
-
Discipline:
Haemostasis
Haemostasis
-
Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
-
Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
-
Minimum Volume Adult:
2.7mL
2.7mL
-
Minimum Volume Paediatric:
1.3mL
1.3mL
-
Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
-
Sample Stability:
4 hrs
4 hrs
-
Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
-
Freq Analysis:
As required
As required
-
Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
-
Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
-
Reference Ranges:
Negative <0.5 BU
Negative <0.5 BU
-
Routine Contact Name:
RVI or Freeman Section Leaders
-
Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
-
Specialist Telephone:
0191 2139758
0191 2139758
-
Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net