Inhibitor Screen
Clinical Background:
Coagulation factor inhibitors may develop in patients with congenital factor deficiencies who are receiving factor replacement therapy if their immune system recognises the product as a foreign pro...
Coagulation factor inhibitors may develop in patients with congenital factor deficiencies who are receiving factor replacement therapy if their immune system recognises the product as a foreign protein, they may also develop in previously normal individuals (acquired factor deficiency). Inhibitors when present complicate therapy and may be the cause of a signficant bleeding disorder. Patients on replacement therapy are screened for inhibitor development every 3 - 6 months as part of the routine monitoring. Inhibitors when present need to be differentiated from non-specific inhibitors such as Lupus Anticoagulant and also need to be quantified if they are directed against a specific coagulation factor (see Inhibitor Titre)
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
Normal = Negative
Normal = Negative
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Other Info:
Helps to distinguish whether prolonged coagulation times are due to the presence of inhibitor which interferes with coagulation factors.
Helps to distinguish whether prolonged coagulation times are due to the presence of inhibitor which interferes with coagulation factors.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net