Infliximab
Clinical Background:
The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring ...
The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring drug levels allows for a personalised approach to drug optimisation by appropriate dose escalation/de-escalation or drug switching/withdrawal.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum
Serum
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Specimen Container Paediatric:
Serum
Serum
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Minimum Volume Adult:
Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis
Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis
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Minimum Volume Paediatric:
Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis
Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis
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Special Requirement:
Ideally take sample just before drug administration (trough level)
Ideally take sample just before drug administration (trough level)
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Sample Stability:
Keep in fridge until transport.
If transport is going to be delayed by > 5 days, freeze at -20°C
Keep in fridge until transport.
If transport is going to be delayed by > 5 days, freeze at -20°C
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Transport Requirements:
First class post at ambient temperature
First class post at ambient temperature
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Quality Assurance:
CTCB Biotherapy
CTCB Biotherapy
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Other Info:
Analysis will include BOTH drug and anti-drug antibody analysis
Analysis will include BOTH drug and anti-drug antibody analysis
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email:
nuth.autoimmunity@nhs.net