Newcastle Laboratories

Immunoglobulins (IgG, IgA, IgM)

Clinical Background:

Guidelines for the Interpretation and Management of immunoglobulins and Paraproteins in Adults.pdf

 

Measurement of serum immunoglobulins is indicated in the investigation of suspected myeloma, Wal...

Guidelines for the Interpretation and Management of immunoglobulins and Paraproteins in Adults.pdf

 

Measurement of serum immunoglobulins is indicated in the investigation of suspected myeloma, Waldenstrom’s macroglobulinaemia, lymphoma and immunodeficiency. The measurement of immunoglobulins is always accompanied by serum electrophoresis, as this is essential for the interpretation of results. Polyclonal elevations of all classes of immunoglobulins may be seen in chronic infection (e.g. HIV) or inflammation (e.g. Sjogren’s syndrome and sarcoidosis). IgA may be raised in chronic infections, lung disease, the elderly and in some cases of liver disease (e.g. cirrhosis). A raised IgM may be seen in acute infections and is a feature of primary biliary cirrhosis.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Specimen Container Paediatric:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Minimum Volume Adult:

    2 ml

    2 ml

  • Minimum Volume Paediatric:

    1 ml

    1 ml

  • Sample Stability:

    IgA
    Unseparated sample: 8 days
    Separated sample: 8 months at 15-25oC, 2-8oC and -20oC

    IgG
    Unseparated sample: 11 days
    Separated sample: 4 months at 15-25oC, 8 months at 2-8oC and -20oC

    IgM
    Unsepa...

    IgA
    Unseparated sample: 8 days
    Separated sample: 8 months at 15-25oC, 2-8oC and -20oC

    IgG
    Unseparated sample: 11 days
    Separated sample: 4 months at 15-25oC, 8 months at 2-8oC and -20oC

    IgM
    Unseparated sample: 17 days
    Separated sample: 2 months at 15-25oC, 4 months at 2-8oC, 6 months at -20oC

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  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    or

    tnu-tr.bloodsciencesadditions...

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    or

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS for Monoclonal Protein Identification

    UK NEQAS for Specific Proteins

    UK NEQAS for Monoclonal Protein Identification

    UK NEQAS for Specific Proteins

  • Interpretation:

    Significant immunodeficiency may be present with normal immunoglobulins, further investigations may include specific antibodies or IgG subclasses, and these should be requested after discussion wit...

    Significant immunodeficiency may be present with normal immunoglobulins, further investigations may include specific antibodies or IgG subclasses, and these should be requested after discussion with an immunologist (adult or paediatric).

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  • Reference Ranges:

    Rerence ranges:

     

    Age rangeIgA (g/L)IgG (g/L)
    0 - 14d 0.01 - 0.08 5.0 - 17.0
    2w - 5w 0.02 - 0.15 3.9 - 13.0
    6w - 2m 0.05 - 0.40 2.1 - 7.7
    3m - 5m 0.10 - 0.50 2.4 - 8.8
    6m - 8m 0.15 - 0.7...

    Rerence ranges:

     

    Age rangeIgA (g/L)IgG (g/L)
    0 - 14d 0.01 - 0.08 5.0 - 17.0
    2w - 5w 0.02 - 0.15 3.9 - 13.0
    6w - 2m 0.05 - 0.40 2.1 - 7.7
    3m - 5m 0.10 - 0.50 2.4 - 8.8
    6m - 8m 0.15 - 0.70 3.0 - 9.0
    9m - 12m 0.20 - 0.70 3.0 - 10.9
    1y 0.30 - 1.20 3.1 - 13.8
    2y 0.30 - 1.30 3.7 - 15.8
    3 - 5y 0.40 - 2.00 4.9 - 16.1
    6 - 8y 0.50 - 2.40 4.9 - 16.1
    9 - 11y 0.70 - 2.50 4.9 - 16.1
    12 - 14y 0.80 - 2.80 5.4 - 16.1
    Adult Male 0.64 - 2.97 5.8 - 15.4
    Adult Female 0.64 - 2.97 5.8 - 15.4

     

    Age rangeIgM (g/L)
    Male   
    0 - 4Y 0.34 - 1.81
    4-9Y 0.36 - 1.86
    10-14Y 0.38 - 1.83
    15-19Y 0.39 - 2.20
    20 - 39Y 0.33 - 2.34
    40 - 59Y 0.28 - 2.35
    60-79Y 0.23 - 2.32
    80 - 99Y 0.20 - 2.20
    Female  
    0 - 4Y 0.43 - 1.95
    4-9Y 0.44 - 2.23
    10-14Y 0.52 - 2.63
    15-19Y 0.50 - 2.69
    20 - 39Y 0.49 - 2.96
    40 - 59Y 0.36 - 2.89
    60-79Y 0.28 - 2.67
    80 - 99Y 0.23 - 2.57

     

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  • Routine Contact Name:

    Proteins Lab

  • Routine Telephone:

    0191 282 4766

    0191 282 4766

  • Routine Email:

Availability:

Serum Immunolglobulin levels are measured on a daily basis Monday to Friday 08:30 to 17:00.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences – RVI

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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