Test Details

• Discipline:

  Immunology

  Immunology

• Specimen Container Adult:

  Serum (SST or plain tube)

  Serum (SST or plain tube)

• Specimen Container Paediatric:

  Serum (SST or plain tube)

  Serum (SST or plain tube)

• Minimum Volume Adult:

  2 ml

  2 ml

• Minimum Volume Paediatric:

  1 ml

  1 ml

• Sample Stability:

  IgA
  Unseparated sample: 8 days
  Separated sample: 8 months at 15-25^oC, 2-8^oC and -20^oC
  
  IgG
  Unseparated sample: 11 days
  Separated sample: 4 months at 15-25^oC, 8 months at 2-8^oC and -20^oC
  
  IgM
  Unsepa...

  IgA
  Unseparated sample: 8 days
  Separated sample: 8 months at 15-25^oC, 2-8^oC and -20^oC
  
  IgG
  Unseparated sample: 11 days
  Separated sample: 4 months at 15-25^oC, 8 months at 2-8^oC and -20^oC
  
  IgM
  Unseparated sample: 17 days
  Separated sample: 2 months at 15-25^oC, 4 months at 2-8^oC, 6 months at -20^oC

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• Freq Analysis:

  Daily

  Daily

• Add On Test:

  All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

  tnu-tr.bloodsciencesadditions@nhs.net (internal)

  or

  tnu-tr.bloodsciencesadditions...

  All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

  tnu-tr.bloodsciencesadditions@nhs.net (internal)

  or

  tnu-tr.bloodsciencesadditions@nhs.net (external)

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• Quality Assurance:

  UK NEQAS for Monoclonal Protein Identification

  UK NEQAS for Specific Proteins

  UK NEQAS for Monoclonal Protein Identification

  UK NEQAS for Specific Proteins

• Interpretation:

  Significant immunodeficiency may be present with normal immunoglobulins, further investigations may include specific antibodies or IgG subclasses, and these should be requested after discussion wit...

  Significant immunodeficiency may be present with normal immunoglobulins, further investigations may include specific antibodies or IgG subclasses, and these should be requested after discussion with an immunologist (adult or paediatric).

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• Reference Ranges:

  ...

  Age range	IgG (g/L)	IgA (g/L)
  0 - 14d	5.0 - 17.0	0.01 - 0.08
  2w - 5w	3.9 - 13.0	0.02 - 0.15
  6w - 2m	2.1 - 7.7	0.05 - 0.40
  3m - 5m	2.4 - 8.8	0.10 - 0.50

  Age range	IgG (g/L)	IgA (g/L)
  0 - 14d	5.0 - 17.0	0.01 - 0.08
  2w - 5w	3.9 - 13.0	0.02 - 0.15
  6w - 2m	2.1 - 7.7	0.05 - 0.40
  3m - 5m	2.4 - 8.8	0.10 - 0.50
  6m - 8m	3.0 - 9.0	0.15 - 0.70
  9m - 12m	3.0 - 10.9	0.20 - 0.70
  1y	3.1 - 13.8	0.30 - 1.20
  2y	3.7 - 15.8	0.30 - 1.30
  3 - 5y	4.9 - 16.1	0.40 - 2.00
  6 - 8y	4.9 - 16.1	0.50 - 2.40
  9 - 11y	4.9 - 16.1	0.70 - 2.50
  12 - 14y	5.4 - 16.1	0.80 - 2.80
  Adult Male	5.8 - 15.4	0.64 - 2.97
  Adult Female	5.8 - 15.4	0.64 - 2.97

   

   

   

   

   

   

   

   

   

   

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  
  

  Age range	Gender	IgM (g/L)
  0 - 14d	All	0.05 - 0.20
  2w - 5w	All	0.08 - 0.40
  6w - 2m	All	0.15 - 0.70
  3m - 5m	All	0.20 - 1.00
  6m - 8m	All	0.40 - 1.60
  9m - 12m	All	0.60 - 2.10
  1y	All	0.60 - 2.10
  2y	All	0.50 - 2.20
  3 - 4y	All	0.50 - 2.00
  5-9Y	M	0.36 - 1.86
  	F	0.44 - 2.23
  10-14Y	M	0.38 - 1.83
  	F	0.52 -  2.63
  15-19Y	M	0.39 - 2.20
  	F	0.50 -  2.69
  20-39Y	M	0.33 -  2.34
  	F	0.33 - 2.34
  40-59Y	M	0.28 -  2.35
  	F	0.36 -  2.89
  60-79Y	M	0.23 -  2.32
  	F	0.28 - 2.67
  80-99Y	M	0.20 -  2.20
  	F	0.23 - 2.57

   

  References:

  IgG and IgA from PRU handbook in Clinical Biochemistry 9^th Edition 2007

  IgM Reference range updated May 2022- based on a Multi-centre study

  Adult ranges from Oxford Handbook of Clinical Immunology and Allergy 3^rd Edition 2013

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• Routine Contact Name:

  Proteins Lab

• Routine Telephone:

  0191 282 4766

  0191 282 4766

• Routine Email:

  tnu-tr.RVI-Proteinlab@nhs.net