Immunoglobulin G (IgG) Subclasses
Clinical Background:
Measurement of IgG subclasses is only indicated as follows:
In the investigation of suspected primary immunodeficiency, after discussion with an immunologist (adult or paediatric).
In the diagnosis...
Measurement of IgG subclasses is only indicated as follows:
In the investigation of suspected primary immunodeficiency, after discussion with an immunologist (adult or paediatric).
In the diagnosis of suspected Sjogren’s syndrome, where the polyclonal increase in IgG is restricted to IgG1.
In the diagnosis of IgG4-related autoimmune diseases.
Test Details
-
Discipline:
Immunology
Immunology
-
Specimen Container Adult:
Serum-SST
Serum-SST
-
Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
-
Minimum Volume Adult:
2 ml
2 ml
-
Minimum Volume Paediatric:
2 ml
2 ml
-
Special Requirement:
None
None
-
Sample Stability:
Stored for 1 year at -80 degrees. Samples should not be freeze thawed prior to testing
Stored for 1 year at -80 degrees. Samples should not be freeze thawed prior to testing
-
Freq Analysis:
Weekly
Weekly
-
Add On Test:
Cannot be added on due to stability issues. Please discuss with the Protein Laboratory
Cannot be added on due to stability issues. Please discuss with the Protein Laboratory
-
Quality Assurance:
UK NEQAS for IgG SUBCLASSES, IMMPROVE Subclass Quality Assurance
UK NEQAS for IgG SUBCLASSES, IMMPROVE Subclass Quality Assurance
-
Interpretation:
Low levels are associated with HAE. However due to stability of C1 esterase inhibitor low levels should be discussed with Immunology
Low levels are associated with HAE. However due to stability of C1 esterase inhibitor low levels should be discussed with Immunology
-
Reference Ranges:
Reference ranges:
Age range (years) IgG1 (g/L) IgG2 (g/L) IgG3 (g/L) IgG4 (g/L) 0 to 2 1.94 – 8.42 0.225-3.0 0.186-0.853 0.005-0.784 2 to 4 3.15 – 9.45 0.36 – 2.25 0.173-0.676 0.001-0.53... Read MoreReference ranges:
Age range (years) IgG1 (g/L) IgG2 (g/L) IgG3 (g/L) IgG4 (g/L) 0 to 2 1.94 – 8.42 0.225-3.0 0.186-0.853 0.005-0.784 2 to 4 3.15 – 9.45 0.36 – 2.25 0.173-0.676 0.001-0.537 4 to 6 3.06 – 9.45 0.605-3.45 0.099-1.221 0.018-1.125 6 to 8 2.88 – 9.18 0.44 – 3.75 0.155-0.853 0.004-0.992 8 to 10 4.32 – 10.20 0.72 – 4.30 0.127-0.853 0.019-0.932 10 to 12 4.23 – 10.60 0.76-3.5 0.173-1.730 0.016-1.15 12 to 14 3.42 – 11.50 1.00 – 4.5 0.283 – 1.25 0.037-1.360 14 to 16 3.15 – 8.55 0.64 – 4.95 0.23 – 1.96 0.11 – 1.57 >16 3.4 - 10.3 1.1 – 9.1 0.17 – 1.7 0.03 – 1.1 Please note update to reference range 01/06/2022
-
Routine Contact Name:
Proteins Lab
-
Routine Telephone:
0191 282 4766
0191 282 4766
-
Routine Email: