Guanidinoacetate and creatine, urine
Clinical Background:
For investigation of suspected metabolic disorders of creatine biosynthesis or transport. These disorders cause intellectual disability, speech impairment and epilepsy due to cerebral creatine def...
For investigation of suspected metabolic disorders of creatine biosynthesis or transport. These disorders cause intellectual disability, speech impairment and epilepsy due to cerebral creatine deficiency.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Urine
Urine
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Specimen Container Paediatric:
Urine
Urine
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Minimum Volume Adult:
1 mL
1 mL
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Minimum Volume Paediatric:
1 mL
1 mL
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Special Requirement:
Freeze as soon as possible, within 2 hours if possible.
Freeze as soon as possible, within 2 hours if possible.
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Transport Requirements:
NuTH Trust users: send sample to the laboratory to arrive within 2 hours
External users: freeze the urine sample within 2 hours of collection and keep frozen during transport.
NuTH Trust users: send sample to the laboratory to arrive within 2 hours
External users: freeze the urine sample within 2 hours of collection and keep frozen during transport.
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Reference Ranges:
Creatine < 5 years 6 – 1303 µmol/mmol creatinine
5 – 12 years 9 – 617 µmol/mmol creatinine
> 12 years ...
Read MoreCreatine < 5 years 6 – 1303 µmol/mmol creatinine
5 – 12 years 9 – 617 µmol/mmol creatinine
> 12 years 5 – 58 µmol/mmol creatinine
Guanidinoacetate < 4 years 19 – 210 µmol/mmol creatinine
4 – 12 years 10 – 125 µmol/mmol creatinine
> 12 years 10 – 69 µmol/mmol creatinine
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Factors Affecting Result:
Creatine is produced by metabolism of creatinine in urine at ambient temperature which may result in falsely elevated results if samples are not frozen promptly.
Creatine is produced by metabolism of creatinine in urine at ambient temperature which may result in falsely elevated results if samples are not frozen promptly.
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email:
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Metabolic Clinical Scientist
Metabolic Clinical Scientist
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Specialist Telephone:
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
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Specialist Email: