Glycolate (PH metabolites)
Clinical Background:
May indicate primary hyperoxaluria if raised along with raised oxalate but is not specific for type 1.
New assay introduced to measure other metabolites in addition to glycolate that are excreted by...
May indicate primary hyperoxaluria if raised along with raised oxalate but is not specific for type 1.
New assay introduced to measure other metabolites in addition to glycolate that are excreted by patients with primary hyperoxaluria (PH). This replaces the previous glycolate assay and includes three additional analytes: glycerate, 4-hydroxy-2-oxoglutarate and dihydroxyglutarate.
We recommend measuring PH metabolites in cases of unexplained hyperoxaluria where it can help to identify those in whom genetic testing is indicated.
Test Details
-
Discipline:
Biochemistry
Biochemistry
-
Specimen Container Adult:
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
-
Specimen Container Paediatric:
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
-
Minimum Volume Adult:
10 mL
10 mL
-
Minimum Volume Paediatric:
10 mL
10 mL
-
Special Requirement:
Need to provide urine oxalate excretion result with request.
Need to provide urine oxalate excretion result with request.
-
Transport Requirements:
-
Reference Ranges:
Glycolate excretion 140-620umol/24h (correct to 1.73m2 for children)
Glycolate:creatinine ratio:
Under 1 yr: 1-49 μmol/mmol creatinine
1 - 4 years: 2-54 μmol/mmol creatinine
5 - 11 years: 1-68 μmol/mm...Read MoreGlycolate excretion 140-620umol/24h (correct to 1.73m2 for children)
Glycolate:creatinine ratio:
Under 1 yr: 1-49 μmol/mmol creatinine
1 - 4 years: 2-54 μmol/mmol creatinine
5 - 11 years: 1-68 μmol/mmol creatinine
>12 years: 14-57 μmol/mmol creatinine
Glycerate:creatinine ratio
<100 μmol/mmol creatinine
HOG:creatinine ratio
<11 μmol/mmol creatinine
DHG:creatinine ratio
<40 μmol/mmol creatinine -
Routine Contact Name:
Duty Biochemist
-
Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
-
Routine Email:
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Metabolic Clinical Scientist
Metabolic Clinical Scientist
-
Specialist Telephone:
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
-
Specialist Email: