Ganglioside Antibodies
Clinical Background:
Ganglioside antibodies are a group of autoantibodies with specificity for antigens particularly found in peripheral nerves. They are useful in the diagnosis and classification of autoimmune periphe...
Ganglioside antibodies are a group of autoantibodies with specificity for antigens particularly found in peripheral nerves. They are useful in the diagnosis and classification of autoimmune peripheral neuropathies. Every antibody that you would like to be tested should be requested separately, though only one tube would be required. Antibodies to GM-1 are associated with Guillain-Barré syndrome, chronic demyelinating polyneuropathy and multifocal motor neuropathy. Antibodies to GQ1b have been associated with the Miller Fisher variant of Guillain-Barré syndrome. Antibodies to GD1a are associated with motor and sensory neuropathies, including variants of Guillain-Barré syndrome. Antibodies to GD1b are highly specific for a rare form of chronic ataxic neuropathy (CANOMAD). Other specificities may be available through referral laboratories after discussion with Immunology Clinical staff.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
2 ml
2 ml
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Minimum Volume Paediatric:
2 ml
2 ml
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Special Requirement:
None
None
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Add On Test:
All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to
All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to
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Interpretation:
None
None
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Reference Ranges:
Normal Ranges; Anti-GM-1: 0 - 200 Titre
Anti-GQ1b: 0 - 25 Titre
Anti-GD1a: 0 - 500 Titre
Anti-GD1b: 0 - 500 Titre
Normal Ranges; Anti-GM-1: 0 - 200 Titre
Anti-GQ1b: 0 - 25 Titre
Anti-GD1a: 0 - 500 Titre
Anti-GD1b: 0 - 500 Titre
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Other Info:
Reported as Negative or a titration value for Positive samples.
Reported as Negative or a titration value for Positive samples.
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: