Newcastle Laboratories

Ganglioside Antibodies

Clinical Background:

Ganglioside antibodies are a group of autoantibodies with specificity for antigens particularly found in peripheral nerves. They are useful in the diagnosis and classification of autoimmune periphe...

Ganglioside antibodies are a group of autoantibodies with specificity for antigens particularly found in peripheral nerves. They are useful in the diagnosis and classification of autoimmune peripheral neuropathies. Every antibody that you would like to be tested should be requested separately, though only one tube would be required. Antibodies to GM-1 are associated with Guillain-Barré syndrome, chronic demyelinating polyneuropathy and multifocal motor neuropathy. Antibodies to GQ1b have been associated with the Miller Fisher variant of Guillain-Barré syndrome. Antibodies to GD1a are associated with motor and sensory neuropathies, including variants of Guillain-Barré syndrome. Antibodies to GD1b are highly specific for a rare form of chronic ataxic neuropathy (CANOMAD). Other specificities may be available through referral laboratories after discussion with Immunology Clinical staff.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    2 ml

    2 ml

  • Minimum Volume Paediatric:

    2 ml

    2 ml

  • Special Requirement:

    None

    None

  • Add On Test:

    All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to 

    nuth.autoimmunity@nhs.net

    All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to 

    nuth.autoimmunity@nhs.net

  • Interpretation:

    None

    None

  • Reference Ranges:

    Normal Ranges; Anti-GM-1: 0 - 200 Titre

    Anti-GQ1b: 0 - 25 Titre

    Anti-GD1a: 0 - 500 Titre

    Anti-GD1b: 0 - 500 Titre

    Normal Ranges; Anti-GM-1: 0 - 200 Titre

    Anti-GQ1b: 0 - 25 Titre

    Anti-GD1a: 0 - 500 Titre

    Anti-GD1b: 0 - 500 Titre

  • Other Info:

    Reported as Negative or a titration value for Positive samples.

    Reported as Negative or a titration value for Positive samples.

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

Availability:

Sent to an external laboratory for testing.

Turn Around:

30 Days

Send To:

Department of Blood Sciences – RVI

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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