Ganciclovir Level
Clinical Background:
Assay to quantify levels of the antiviral ganciclovir in blood. Routine monitoring of patients on ganciclovir/valganciclovir is not recommended. Levels may be useful in certain situations such as; ...
Assay to quantify levels of the antiviral ganciclovir in blood. Routine monitoring of patients on ganciclovir/valganciclovir is not recommended. Levels may be useful in certain situations such as; to confirm adequate drug levels where CMV levels remain high despite adequate drug dosing, where there are concerns regarding absorption in patients on oral treatment, where pharmokinetics are variable as in renal failure or young infants. For patients on IV ganciclovir levels should be send before the dose and 1 hr after. For oral valganciclovir levels should be send before the dose and 2 hrs after.
Test Details
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Discipline:
Microbiology
Microbiology
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Specimen Container Adult:
Clotted blood - Gold SST
Clotted blood - Gold SST
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Specimen Container Paediatric:
Clotted blood
Clotted blood
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Minimum Volume Adult:
5 ml
5 ml
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Minimum Volume Paediatric:
1 ml
1 ml
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Special Requirement:
Send to laboratory as quickly as possible. If delays likely, refrigerate at 2-8 deg C
Send to laboratory as quickly as possible. If delays likely, refrigerate at 2-8 deg C
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Sample Stability:
Stable for up to 24 hours
Stable for up to 24 hours
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Transport Requirements:
Standard
Standard
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Add On Test:
N/A
N/A
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Quality Assurance:
Sample referred to Reference Laboratory
Sample referred to Reference Laboratory
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Interpretation:
Expected levels (mg/L) Pre 0.5-1.0 ...
Expected levels (mg/L) Pre 0.5-1.0 Post 7-9 (ganciclovir) Post 5-7 (valganciclovir) Re-assay interval 4-8d
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Other Info:
Sample referred to Antimicrobial Reference Laboratory, Bristol
Sample referred to Antimicrobial Reference Laboratory, Bristol