Test Details

• Discipline:

  Microbiology

  Microbiology

• Specimen Container Adult:

  Clotted blood - Gold SST

  Clotted blood - Gold SST

• Specimen Container Paediatric:

  Clotted blood

  Clotted blood

• Minimum Volume Adult:

  5 ml

  5 ml

• Minimum Volume Paediatric:

  1 ml

  1 ml

• Special Requirement:

  Routinely monitor levels within 72h of starting therapy with systemic flucytosine.

  Pre-dose (trough) clotted blood (serum) samples should be taken just before a dose of flucytosine.

  Pose-dose (pea...

  Routinely monitor levels within 72h of starting therapy with systemic flucytosine.

  Pre-dose (trough) clotted blood (serum) samples should be taken just before a dose of flucytosine.

  Pose-dose (peak) clotted blood (serum) samples should be taken 30 minutes after an intravenous dose, or  2 hours after an oral dose.

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• Sample Stability:

  Send to laboratory as quickly as possible.

  Send to laboratory as quickly as possible.

• Transport Requirements:

  Send to laboratory as quickly as possible.

  Send to laboratory as quickly as possible.

• Add On Test:

  N/A

  N/A

• Quality Assurance:

  UKNEQAS

  UKNEQAS

• Interpretation:

  The dose and interval should be adjusted in order to produce target peak and trough serum concentrations.

  Expected levels, according to 2017 Bristol Antimicrobial Reference Laboratory – Guideline R...

  The dose and interval should be adjusted in order to produce target peak and trough serum concentrations.

  Expected levels, according to 2017 Bristol Antimicrobial Reference Laboratory – Guideline Ranges:

  Pre-dose (trough) target level: 20-40 mg/L

  Post-dose (peak) target level: 50-100mg/L

  Pre-dose (trough) concentrations <20 mg/L have been associated with treatment failure and emergence of resistance.

  Post-dose (peak) concentrations >100 mg/L have been associated with toxicity.

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• Referenced Documents:

  Sources of information include the TDM assay guide (Bristol) https://www.newcastlelaboratories.com/antibiotic-assay-guide-2017-bristol and the Mycology Reference Lab website https://www.gov.uk/guid...

  Sources of information include the TDM assay guide (Bristol) https://www.newcastlelaboratories.com/antibiotic-assay-guide-2017-bristol and the Mycology Reference Lab website https://www.gov.uk/guidance/mycology-reference-laboratory-mrl-reference-and-diagnostic-services#assay-results-interpretation

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