FIX Refixia
Clinical Background:
Refixia is pegylated Haemophilia B FIX prophylaxis for the treatment and prevention of bleeding episodes. Due to interference from the polyethylene glycol (PEG) in one-stage clotting assays with ou...
Refixia is pegylated Haemophilia B FIX prophylaxis for the treatment and prevention of bleeding episodes. Due to interference from the polyethylene glycol (PEG) in one-stage clotting assays with our standard aPTT reagent (SynthasIL), a modified one stage FIX must be performed using an alternative, non-silica based aPTT reagent (SynthAFax).
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue – sodium citrate
Light blue – sodium citrate
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Specimen Container Paediatric:
Light blue – sodium citrate
Light blue – sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hours
4 hours
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS
UK NEQAS
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Factors Affecting Result:
SynthAFax reagent must be mixed well by inversion several times prior to use
SynthAFax reagent must be mixed well by inversion several times prior to use
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Other Info:
The Refixia assay is a Factor IX assay which uses Hemosil SynthAFax as the APTT reagent
The Refixia assay is a Factor IX assay which uses Hemosil SynthAFax as the APTT reagent
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Routine Email:
Emily.lloyd21@nhs.net
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net