Newcastle Laboratories

Fibrinogen - Derived

Clinical Background:

This is a calculated parameter derived from the PT reaction and is used as part of the clotting screen. When a clot forms in anticoagulated plasma, there is a change in state caused by the precipit...

This is a calculated parameter derived from the PT reaction and is used as part of the clotting screen. When a clot forms in anticoagulated plasma, there is a change in state caused by the precipitation of soluble fibrinogen being converted to fibrin which precipitates and cross links with more fibrin forming a clot. The change in state can be followed by a number of coagulation analysers where it is seen as a reduction in light transmission through the test cuvette.The change is then converted into a concentration of Fibrinogen by use of a calibration curve prepared from plasma with a known fibrinogen concentration. This measurement is not applicable in cases where there is on-going fibrinolysis (acute DIC or Fibrinoyltic therapy) but will give an indication of the Fibrinogen level in the majority of cases

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    2.7mL

    2.7mL

  • Minimum Volume Paediatric:

    1.3mL

    1.3mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    24 hrs

    24 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    Continuous

    Continuous

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nh...

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    Fibrinogen (derived) 2.1 - 4.8g/L

    Fibrinogen (derived) 2.1 - 4.8g/L

  • Other Info:

    As part of a coagulation screen.

    As part of a coagulation screen.

  • Routine Contact Name:

    Peter Strong

  • Routine Telephone:

    0191 282 0332

    0191 282 0332

  • Routine Email:

  • Specialist Test:

    No

    No

  • Specialist Contact Name:

    Haematology/Haemostasis Health care Scientist

    Haematology/Haemostasis Health care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

All times, both sites

Turn Around:

Urgent within 1 hour.

Routine within 4 hours.

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