Fibrinogen - Derived
Clinical Background:
This is a calculated parameter derived from the PT reaction and is used as part of the clotting screen. When a clot forms in anticoagulated plasma, there is a change in state caused by the precipit...
This is a calculated parameter derived from the PT reaction and is used as part of the clotting screen. When a clot forms in anticoagulated plasma, there is a change in state caused by the precipitation of soluble fibrinogen being converted to fibrin which precipitates and cross links with more fibrin forming a clot. The change in state can be followed by a number of coagulation analysers where it is seen as a reduction in light transmission through the test cuvette.The change is then converted into a concentration of Fibrinogen by use of a calibration curve prepared from plasma with a known fibrinogen concentration. This measurement is not applicable in cases where there is on-going fibrinolysis (acute DIC or Fibrinoyltic therapy) but will give an indication of the Fibrinogen level in the majority of cases
Test Details
-
Discipline:
Haemostasis
Haemostasis
-
Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
-
Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
-
Minimum Volume Adult:
2.7mL
2.7mL
-
Minimum Volume Paediatric:
1.3mL
1.3mL
-
Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
-
Sample Stability:
24 hrs
24 hrs
-
Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
-
Freq Analysis:
Continuous
Continuous
-
Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
-
Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
-
Reference Ranges:
Fibrinogen (derived) 2.1 - 4.8g/L
Fibrinogen (derived) 2.1 - 4.8g/L
-
Other Info:
As part of a coagulation screen.
As part of a coagulation screen.
-
Routine Contact Name:
RVI or Freeman Section Leaders
-
Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
-
Specialist Test:
No
No
-
Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
-
Specialist Telephone:
0191 2139758
0191 2139758
-
Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net