Newcastle Laboratories

Factor XI Assay

Clinical Background:

Factor XI (also known as plasma thromboplastin antecedant) is a non-vitamin K sensitive coagulation factor, produced in the liver. Factor XI is activated by Factor XIIa, Factor Xia then activates F...

Factor XI (also known as plasma thromboplastin antecedant) is a non-vitamin K sensitive coagulation factor, produced in the liver. Factor XI is activated by Factor XIIa, Factor Xia then activates Factor IX. Deficiency of Factor XI is sometimes referred to as Haemophilia C. It is a heterogenous disorder with Factor levels not always indicating bleeding tendancy. The PT is normal and the APTT is prolonged in Factor XI deficiency

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    2.7mL

    2.7mL

  • Minimum Volume Paediatric:

    1.3mL

    1.3mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    4 hrs

    4 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    As required or weekly

    As required or weekly

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nh...

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    70 - 160%

    70 - 160%

  • Other Info:

    A quantitative assay of coagulation factor XI.

    A quantitative assay of coagulation factor XI.

  • Routine Contact Name:

    Peter Strong

  • Routine Telephone:

    0191 282 0332

    0191 282 0332

  • Routine Email:

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health care Scientist

    Haematology/Haemostasis Health care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

Discuss with laboratory.

Out of hours discuss with on call Specialist Registrar.

Turn Around:

7 days, urgent on request

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