Newcastle Laboratories

Factor V Leiden Mutation

Clinical Background:

Factor V Leiden is a variant form of human factor V that is associated with an increased risk of thrombosis. Due to the mutation, in which arginine is replaced with glutamine, activated protein C i...

Factor V Leiden is a variant form of human factor V that is associated with an increased risk of thrombosis. Due to the mutation, in which arginine is replaced with glutamine, activated protein C is unable to bind normally to activated factor V and downregulate the prothrombotic action, resulting in an increased thrombotic tendency.

Factor V Leiden is the most common hereditary hypercoagulability disorder amongst ethnic Europeans   

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue- sodium citrate 

    Light blue- sodium citrate 

  • Specimen Container Paediatric:

    Light blue – sodium citrate (semi-transparent cap)

    Light blue – sodium citrate (semi-transparent cap)

  • Minimum Volume Adult:

    Single whole blood sample                       

    Single whole blood sample                       

  • Minimum Volume Paediatric:

    Single whole blood sample                       

    Single whole blood sample                       

  • Sample Stability:

    7 days @4°C

    7 days @4°C

  • Transport Requirements:

    Samples should be transported to the laboratory without delay 

    Samples should be transported to the laboratory without delay 

  • Freq Analysis:

    Fortnightly or urgent as required 

    Fortnightly or urgent as required 

  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    Prevalence in general population                                             5%

    Prevalence in patients presenting with DVT or PE             30%

    ...

    Prevalence in general population                                             5%

    Prevalence in patients presenting with DVT or PE             30%

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  • Other Info:

    Thrombotic risk

    Heterozygote                                                    4 to 8 fold increase

    Homozygote                                                      40 – 80 fold increase

     

    Increase...

    Thrombotic risk

    Heterozygote                                                    4 to 8 fold increase

    Homozygote                                                      40 – 80 fold increase

     

    Increased risk of thrombosis in pregnancy

    Increased risk with Oestrogen containing oral contraception      

     

     

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  • Routine Contact Name:

    Protein Laboratory RVI

  • Routine Telephone:

    0191 2824766

    0191 2824766

  • Routine Email:

    paul.murphy4@nhs.net

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health Care Scientist

    Haematology/Haemostasis Health Care Scientist

  • Specialist Telephone:

    0191 2139758

    0191 2139758

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