Factor V Assay
Clinical Background:
Factor V (also known as Pro-accelerin or Labile Factor) is a non-vitamin K sensitive coagulation protein synthesised in the liver. Congenital deficiencies are rare (1 in 1 million) but acquired def...
Factor V (also known as Pro-accelerin or Labile Factor) is a non-vitamin K sensitive coagulation protein synthesised in the liver. Congenital deficiencies are rare (1 in 1 million) but acquired deficiency due to liver disease are much more common (the assay may be used to assess the severity of liver disease). Factor V is a catalyst in the formation of thrombin, it is inherited in an autosomal recessive manner and deficiencies cause a bleeding disorder. PT and APTT are prolonged with reduced Factor V levels
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
50 - 150IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges.
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
50 - 150IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges.
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
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Other Info:
A quantitative assay of coagulation factor V.
A quantitative assay of coagulation factor V.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net