Newcastle Laboratories

Elastase, faecal

Clinical Background:

Faecal elastase is a pancreatic-specific enzyme that is useful in the investigation of children with suspected or diagnosed Cystic Fibrosis as well as the investigation of the patient with possible...

Faecal elastase is a pancreatic-specific enzyme that is useful in the investigation of children with suspected or diagnosed Cystic Fibrosis as well as the investigation of the patient with possible exocrine pancreatic insufficiency, such as chronic pancreatitis, diabetes mellitus and cholelithiasis. Pancreatic elastase-1 remains unaffected and undegraded during intestinal passage such that its concentration in faeces accurately reflects the amount of enzyme secreted from the pancreas. Estimation of the faecal concentration allows for the accurate assessment of exocrine pancreatic function.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    White universal container, random faeces

    White universal container, random faeces

  • Specimen Container Paediatric:

    White universal container, random faeces

    White universal container, random faeces

  • Minimum Volume Adult:

    5 g faeces

    5 g faeces

  • Minimum Volume Paediatric:

    5 g faeces

    5 g faeces

  • Special Requirement:

    Not recommended in watery samples because of dilution effect.

    Not recommended in watery samples because of dilution effect.

  • Sample Stability:

    Stool samples are stable at 4°C for up to 3 days.

    For long-term storage, samples can be stored at -20°C for up to 6 months.

    Stool samples are stable at 4°C for up to 3 days.

    For long-term storage, samples can be stored at -20°C for up to 6 months.

  • Transport Requirements:

    Ambient temperature.

    Ambient temperature.

  • Quality Assurance:

    Inter-Laboratory Sample Exchange

    Inter-Laboratory Sample Exchange

  • Interpretation:

    Pancreatic exocrine insufficiency can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumour, cholelithiasis or diabetes mellitus.

    Pancreatic exocrine insufficiency can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumour, cholelithiasis or diabetes mellitus.

  • Reference Ranges:

    Normal exocrine pancreatic function: greater than 200 µg/g faeces
    Moderate/slight exocrine pancreatic insufficiency: 100 - 200 µg/g faeces
    Severe exocrine pancreatic insufficiency: less than 100 µg...

    Normal exocrine pancreatic function: greater than 200 µg/g faeces
    Moderate/slight exocrine pancreatic insufficiency: 100 - 200 µg/g faeces
    Severe exocrine pancreatic insufficiency: less than 100 µg/g faeces

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  • Factors Affecting Result:

    No known interferences, including enzyme replacement therapy.

    No known interferences, including enzyme replacement therapy.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

  • Specialist Test:

    Yes

    Yes

Availability:

Available during full access hours
Assayed as service demands
Site of analysis: Freeman

Turn Around:

Within 1 weeks

Send To:

Department of Blood Sciences

Freeman Hospital
Freeman Road
Newcastle upon Tyne
NE7 7DN

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