eGFR
Clinical Background:
Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration in the CKI-EPI based calculation. Serum [creatinine] can be used together with demogra...
Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration in the CKI-EPI based calculation. Serum [creatinine] can be used together with demographic information (e.g. age, race, sex) to calculate an estimated GFR (eGFR). In the UK, it is recommended that eGFR should be based on the 2009 CKD-Epi creatinine equation formula. However, this is not applicable to several clinical situations e.g. acute kidney disease, children, individuals with muscle‐wasting etc. In patients with CKD stages 1‐3 (i.e. eGFR ≥60 mL/min) measurements should be made 6‐ or at least 12‐ monthly according to whether eGFR is changing by more or less than 15 mL/min, respectively, between successive measurements; in patients with more advanced CKD, the corresponding figures are 3‐ and 6‐monthly.
Gender Serum creatinine Equation for estimating GFR using CKD-Epi creatinine equation (2009):
Female ≤62 mmol/l eGFR = 144x(SCr/0.7)-0.329 x 0.993Age x 1.018
Female >62 mmol/l eGFR = 144x(SCr/0.7)-1.209 x 0.993Age x 1.018
Male ≤80 mmol/l eGFR = 141x(SCr/0.9)-0.411 x 0.993Age
Male >80 mmol/l eGFR = 141x(SCr/0.9)-1.209 x 0.993Age
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
0.5ml blood for Creatinine
0.5ml blood for Creatinine
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Minimum Volume Paediatric:
0.5ml blood for Creatinine
0.5ml blood for Creatinine
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Sample Stability:
For Creatinine- after separation
at +15° to +25°C: 7 days
at +2° to +8°C: 7 days
at -15° to -25°C: 3 monthsFor Creatinine- after separation
at +15° to +25°C: 7 days
at +2° to +8°C: 7 days
at -15° to -25°C: 3 months -
Reference Ranges:
>90 ml/min/1.73m2 - Normal GFR, Should be considered normal unless there is other evidence of renal disease
60-89 ml/min/1.73m2 - Should be considered normal unless there is other evidence of rena...Read More>90 ml/min/1.73m2 - Normal GFR, Should be considered normal unless there is other evidence of renal disease
60-89 ml/min/1.73m2 - Should be considered normal unless there is other evidence of renal disease
30-59 ml/min/1.73m2 - Consistent with moderate renal impairment. Recommend repeat U/E within 5 days if reduced eGFR not already known
15-29 ml/min/1.73m2 - Consistent with severe renal impairment. Recommend repeat U/E within 5 days if reduced eGFR not already known. Urgent or non-urgent Nephrology referral may be indicated
<15 ml/min/1.73m2 - Consistent with established renal failure. Recommend urgent referral to Nephrology
Please refer to CKD guidelines for further advice -
Other Info:
Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration with the 2009 CKD-Epi creatinine equation.
Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration with the 2009 CKD-Epi creatinine equation.
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Routine Contact Name:
Duty biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email: