Newcastle Laboratories

eGFR

Clinical Background:

Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration in the CKI-EPI based calculation. Serum [creatinine] can be used together with demogra...

Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration in the CKI-EPI based calculation. Serum [creatinine] can be used together with demographic information (e.g. age, race, sex) to calculate an estimated GFR (eGFR). In the UK, it is recommended that eGFR should be based on the 2009 CKD-Epi creatinine equation formula. However, this is not applicable to several clinical situations e.g. acute kidney disease, children, individuals with muscle‐wasting etc. In patients with CKD stages 1‐3 (i.e. eGFR ≥60 mL/min) measurements should be made 6‐ or at least 12‐ monthly according to whether eGFR is changing by more or less than 15 mL/min, respectively, between successive measurements; in patients with more advanced CKD, the corresponding figures are 3‐ and 6‐monthly.

Gender Serum creatinine Equation for estimating GFR using CKD-Epi creatinine equation (2009):

Female ≤62 mmol/l      eGFR = 144x(SCr/0.7)-0.329 x 0.993Age x 1.018        
Female >62 mmol/l      eGFR = 144x(SCr/0.7)-1.209 x 0.993Age  x 1.018       
Male ≤80 mmol/l          eGFR = 141x(SCr/0.9)-0.411 x 0.993Age         
Male >80 mmol/l          eGFR = 141x(SCr/0.9)-1.209 x 0.993Age         

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    0.5ml blood for Creatinine

    0.5ml blood for Creatinine

  • Minimum Volume Paediatric:

    0.5ml blood for Creatinine

    0.5ml blood for Creatinine

  • Sample Stability:

    For Creatinine- after separation
    at +15° to +25°C: 7 days
    at +2° to +8°C: 7 days
    at -15° to -25°C: 3 months

    For Creatinine- after separation
    at +15° to +25°C: 7 days
    at +2° to +8°C: 7 days
    at -15° to -25°C: 3 months

  • Reference Ranges:

    >90 ml/min/1.73m2 - Normal GFR, Should be considered normal unless there is other evidence of renal disease

    60-89 ml/min/1.73m2 - Should be considered normal unless there is other evidence of rena...

    >90 ml/min/1.73m2 - Normal GFR, Should be considered normal unless there is other evidence of renal disease

    60-89 ml/min/1.73m2 - Should be considered normal unless there is other evidence of renal disease

    30-59 ml/min/1.73m2 - Consistent with moderate renal impairment. Recommend repeat U/E within 5 days if reduced eGFR not already known

    15-29 ml/min/1.73m2 - Consistent with severe renal impairment. Recommend repeat U/E within 5 days if reduced eGFR not already known. Urgent or non-urgent Nephrology referral may be indicated

    <15 ml/min/1.73m2 - Consistent with established renal failure. Recommend urgent referral to Nephrology

    Please refer to CKD guidelines for further advice

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  • Other Info:

    Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration with the 2009 CKD-Epi creatinine equation.

    Estimated glomerular filtration rate (eGFR) is a calculated parameter using the serum creatinine concentration with the 2009 CKD-Epi creatinine equation.

  • Routine Contact Name:

    Duty biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

  • Routine Email:

Availability:

All times at all sites

Turn Around:

Urgent: wihin 1 hour; non-urgent: within 1 day

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