Newcastle Laboratories

Double-stranded DNA Antibodies

Clinical Background:

Elevated levels of ds-DNA antibodies are found in many cases of SLE and in some cases of autoimmune chronic active hepatitis. ds-DNA antibodies are not found in other connective tissue diseases.

Elevated levels of ds-DNA antibodies are found in many cases of SLE and in some cases of autoimmune chronic active hepatitis. ds-DNA antibodies are not found in other connective tissue diseases.

Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1 ml

    1 ml

  • Minimum Volume Paediatric:

    1 ml

    1 ml

  • Special Requirement:

    None

    None

  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    or

    tnu-tr.bloodsciencesadditions...

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net (internal)

    or

    tnu-tr.bloodsciencesadditions@nhs.net (external)

    Read More
  • Quality Assurance:

    UK NEQAS for Antibodies to Nuclear and Related Antigens

    UK NEQAS for Antibodies to Nuclear and Related Antigens

  • Interpretation:

    In SLE a rising titre may predict relapse, however, as the half-life of circulating antibodies is 3 weeks it is not useful to measure ds-DNA antibody levels more frequently than this.

    In SLE a rising titre may predict relapse, however, as the half-life of circulating antibodies is 3 weeks it is not useful to measure ds-DNA antibody levels more frequently than this.

  • Reference Ranges:

    Normal Adult Range: Negative

    1 - 4 IU/ml: Negative

    5 - 8 IU/ml: Borderline

    9 - 300 IU/ml: Positive

    >300 IU/ml: Strongly positive

    Normal Adult Range: Negative

    1 - 4 IU/ml: Negative

    5 - 8 IU/ml: Borderline

    9 - 300 IU/ml: Positive

    >300 IU/ml: Strongly positive

  • Other Info:

    Results are reported as a value.

    Results are reported as a value.

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

Availability:

ds-DNA antibodies are detected by BioPlex 2200 multiplex analyser and are run on a daily basis.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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