Double-stranded DNA Antibodies
Clinical Background:
Elevated levels of ds-DNA antibodies are found in many cases of SLE and in some cases of autoimmune chronic active hepatitis. ds-DNA antibodies are not found in other connective tissue diseases.
Elevated levels of ds-DNA antibodies are found in many cases of SLE and in some cases of autoimmune chronic active hepatitis. ds-DNA antibodies are not found in other connective tissue diseases.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1 ml
1 ml
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Minimum Volume Paediatric:
1 ml
1 ml
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Special Requirement:
None
None
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Freq Analysis:
Daily
Daily
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Add On Test:
All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to the appropriate email address
All urgent add ons via telephone on 0191 2821890 , and must be confirmed via email to the appropriate email address
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Quality Assurance:
UK NEQAS for Antibodies to Nuclear and Related Antigens
UK NEQAS for Antibodies to Nuclear and Related Antigens
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Interpretation:
In SLE a rising titre may predict relapse, however, as the half-life of circulating antibodies is 3 weeks it is not useful to measure ds-DNA antibody levels more frequently than this.
In SLE a rising titre may predict relapse, however, as the half-life of circulating antibodies is 3 weeks it is not useful to measure ds-DNA antibody levels more frequently than this.
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Reference Ranges:
Normal Adult Range: Negative
1 - 4 IU/ml: Negative
5 - 8 IU/ml: Borderline
9 - 300 IU/ml: Positive
>300 IU/ml: Strongly positive
Normal Adult Range: Negative
1 - 4 IU/ml: Negative
5 - 8 IU/ml: Borderline
9 - 300 IU/ml: Positive
>300 IU/ml: Strongly positive
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Other Info:
Results are reported as a value.
Results are reported as a value.
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: