Dihydrotestosterone
Clinical Background:
5-alpha-reductase converts testosterone, DHEA and androstenedione into DHT. DHT is responsible for external mascularisation of males. Hence its deficiency leads to ambiguous genitalia in males. Cir...
5-alpha-reductase converts testosterone, DHEA and androstenedione into DHT. DHT is responsible for external mascularisation of males. Hence its deficiency leads to ambiguous genitalia in males. Circulating concentrations are of little significance in females.
To investigate ambiguous genitalia in neonates and young children. To investigate suspicion of 5alpha- reductase deficiency
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum preferred
Lithium Heparin or EDTA acceptableSerum preferred
Lithium Heparin or EDTA acceptable -
Specimen Container Paediatric:
Serum preferred
Lithium Heparin or EDTA acceptableSerum preferred
Lithium Heparin or EDTA acceptable -
Minimum Volume Adult:
2.5 mL blood
2.5 mL blood
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Minimum Volume Paediatric:
2.5 mL blood
2.5 mL blood
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Special Requirement:
Store sample at -20°C
Store sample at -20°C
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Transport Requirements:
Post at ambient temperature
Post at ambient temperature
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Reference Ranges:
Adult male (>16 yr): 0.4 - 1.9 nmol/L
Adult female (>16 yr): <0.5 nmol/L
Adult male (>16 yr): 0.4 - 1.9 nmol/L
Adult female (>16 yr): <0.5 nmol/L
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email: