Deoxypyridinoline (DPD), urine
Clinical Background:
PYD and DPD are normally excreted in the urine, and larger quantities are excreted when bone resorption is increased. In contrast, when bone resorption is inhibited by bisphosphonates, oestrogen, o...
PYD and DPD are normally excreted in the urine, and larger quantities are excreted when bone resorption is increased. In contrast, when bone resorption is inhibited by bisphosphonates, oestrogen, or calcitonin therapy, the excretion of PYD and DPD is decreased. All available data indicate that PYD and DPD derive only from bone matrix degradation and thus are markers of bone resorption, not bone formation.
The assay for pyridinoline collagen cross-links is useful as a sensitive and specific marker in the diagnosis and management of bone loss in osteoporosis. The cross-links assay is also useful in measuring bone resorption in other metabolic bone diseases such as primary hyperparathyroidism and Paget’s disease.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Plain universal container (random urine sample)
Plain universal container (random urine sample)
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Specimen Container Paediatric:
Plain universal container (random urine sample)
Plain universal container (random urine sample)
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Minimum Volume Adult:
10 mL
10 mL
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Minimum Volume Paediatric:
10 mL
10 mL
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Special Requirement:
Protect from UV light in a container or with foil
There is a significant circadian rhythm with higher levels of excretion at night (as much as 50%). It is therefore recommended that a carefully mon...Read MoreProtect from UV light in a container or with foil
There is a significant circadian rhythm with higher levels of excretion at night (as much as 50%). It is therefore recommended that a carefully monitored second void urine is collected.
A baseline pre-treatment measurement is required if assessing response to antiresorption therapy. -
Sample Stability:
Store sample at -20°C
Store sample at -20°C
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email: