Newcastle Laboratories

Ciclosporin, whole blood

Clinical Background:

Ciclosporin is an immunosuppressant that is used to prevent rejection after solid organ (heart, kidney, liver, pancreas or lung) transplantation. Ciclosporin has a narrow therapeutic range with fre...

Ciclosporin is an immunosuppressant that is used to prevent rejection after solid organ (heart, kidney, liver, pancreas or lung) transplantation. Ciclosporin has a narrow therapeutic range with frequent adverse effects making therapeutic drug monitoring essential for monitoring whole blood concentrations during therapy (particularly in individuals co-administered therapeutic drugs), adjusting dose to optimise immunosuppression while minimizing toxicity, and evaluating patient compliance.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Purple - EDTA

    Purple - EDTA

  • Specimen Container Paediatric:

    Pink - EDTA

    Pink - EDTA

  • Minimum Volume Adult:

    0.5 mL blood

    0.5 mL blood

  • Minimum Volume Paediatric:

    0.5 mL blood

    0.5 mL blood

  • Special Requirement:

    Trough sample is recommended.

    Trough sample is recommended.

  • Sample Stability:

    Ciclosporin is stable for at least 12 weeks when stored at 4°C prior to analysis.

    For long-term storage, samples should be stored at -15°C with stability of at least 6 months.

    Ciclosporin is stable for at least 12 weeks when stored at 4°C prior to analysis.

    For long-term storage, samples should be stored at -15°C with stability of at least 6 months.

  • Transport Requirements:

    Ambient temperature.

    Ambient temperature.

  • Quality Assurance:

    International Proficiency Testing Scheme

    International Proficiency Testing Scheme

  • Interpretation:

    Most individuals display optimal response to ciclosporin with C0 trough levels of 100 to 400 ng/mL. Preferred therapeutic ranges may vary by transplant type, length of time post-transplant and unit...

    Most individuals display optimal response to ciclosporin with C0 trough levels of 100 to 400 ng/mL. Preferred therapeutic ranges may vary by transplant type, length of time post-transplant and unit protocols. Please contact the original transplant unit for organ-specific therapeutic ranges.

    Therapeutic ranges are based on trough levels, i.e. blood drawn immediately before a scheduled dose. Blood drawn at other times will yield higher results.

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  • Reference Ranges:

    Therapeutic ranges vary with type of transplant and length of time post transplant.

    Therapeutic ranges vary with type of transplant and length of time post transplant.

  • Factors Affecting Result:

    Therapeutic ranges are based on trough levels, i.e. blood drawn immediately before a scheduled dose. Blood drawn at other times will yield higher results.

    Therapeutic ranges are based on trough levels, i.e. blood drawn immediately before a scheduled dose. Blood drawn at other times will yield higher results.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

  • Specialist Test:

    Yes

    Yes

Availability:

Available during full access hours
Assayed daily
Site of analysis: Freeman
May be available during restricted access hours after discussion between the requesting consultant and the DMO.

Turn Around:

Within 2 full access days

Send To:

Department of Blood Sciences

Freeman Hospital
Freeman Road
Newcastle upon Tyne
NE7 7DN

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