Cholinesterase (pseudocholinestease), phenotype
Clinical Background:
Cholinesterase is an enzyme responsible for the metabolism of the muscle relaxants suxamethonium (scoline) and mivacurium which shows a great deal of genetic variation. Some variants lead to an eff...
Cholinesterase is an enzyme responsible for the metabolism of the muscle relaxants suxamethonium (scoline) and mivacurium which shows a great deal of genetic variation. Some variants lead to an effective enzyme deficiency which impairs an individual’s ability to metabolise the drugs and leads to prolonged paralysis and apnoea.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
EDTA whole blood
EDTA whole blood
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Specimen Container Paediatric:
EDTA whole blood
EDTA whole blood
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Minimum Volume Adult:
5 mL blood
5 mL blood
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Minimum Volume Paediatric:
5 mL blood
5 mL blood
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Special Requirement:
Do not collect sample while patient is still paralysed after possible scoline apnoea.
Do not send on Friday.Do not collect sample while patient is still paralysed after possible scoline apnoea.
Do not send on Friday. -
Sample Stability:
Store sample at 4°C
Store sample at 4°C
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Transport Requirements:
Post
Post
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Reference Ranges:
Provided on report from referral laboratory.
Provided on report from referral laboratory.
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Other Info:
SST serum sample also acceptable
SST serum sample also acceptable
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email: