Chimerism
Clinical Background:
The chimerism investigation is carried out following haematopoietic stem cell transplants to monitor the proportion of host and donor DNA. Chimerism can be performed on whole blood or marrow or sel...
The chimerism investigation is carried out following haematopoietic stem cell transplants to monitor the proportion of host and donor DNA. Chimerism can be performed on whole blood or marrow or selected cells (CD15 for myeloid cells or CD3 for T-cells) and helps determine response to transplantation and level of engraftment. The results can help inform use of donor lymphocyte infusions.
Test Details
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Discipline:
NEHODS
NEHODS
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Specimen Container Adult:
EDTA
EDTA
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Specimen Container Paediatric:
EDTA
EDTA
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Minimum Volume Adult:
5 mL
5 mL
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Minimum Volume Paediatric:
5 mL
5 mL
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Special Requirement:
Please complete NEHODS request form
Please complete NEHODS request form
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Sample Stability:
N/A
N/A
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Transport Requirements:
Samples should be sent to laboratory immediately.
Samples should be sent to laboratory immediately.
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Freq Analysis:
Daily
Daily
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Add On Test:
Can be added to any genetics sample where DNA has been stored
Can be added to any genetics sample where DNA has been stored
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Quality Assurance:
UK NEQAS
UK NEQAS
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Interpretation:
By genetics clinical scientist
By genetics clinical scientist
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Reference Ranges:
N/A
N/A
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Factors Affecting Result:
Quality and size of sample
Quality and size of sample
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Referenced Documents:
N/A
N/A