CGD proteins
Clinical Background:
Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity. It is caused by defects of NADPH oxidase, the enzyme responsible for the producti...
Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity. It is caused by defects of NADPH oxidase, the enzyme responsible for the production of reactive oxygen species needed to kill pathogenic bacteria and fungi. NADPH oxidase has a membrane-bound flavocytochrome b558, which is comprised of gp91phox and p22phox and cytosolic components comprised of p40phox, p47phox and p67phox. Assays for gp91, p22, p47 and p67phox provide additional diagnostic information for CGD following initial abnormal testing by oxidative burst and NBT
Test Details
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Discipline:
Flow Cytometry
Flow Cytometry
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Specimen Container Adult:
Purple top EDTA
Purple top EDTA
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Specimen Container Paediatric:
pink top paediatric EDTA
pink top paediatric EDTA
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Minimum Volume Adult:
4 mL
4 mL
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Minimum Volume Paediatric:
2 mL
2 mL
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Sample Stability:
48 hours
48 hours
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Transport Requirements:
Ambient
Ambient
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Freq Analysis:
As required
As required
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Add On Test:
not possible
not possible
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Reference Ranges:
All CGD proteins should be normally expressed.
All CGD proteins should be normally expressed.
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Routine Contact Name:
Flow Cytometry Lab
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Routine Telephone:
0191 282 5078
0191 282 5078
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Routine Email: