CA 125, serum
Clinical Background:
CA125 is a non-mucinoid glycoprotein with a molecular weight in excess of 200kDa, and carbohydrate content of approximately 25%. It circulates in the serum in association with another glycoprotein ...
CA125 is a non-mucinoid glycoprotein with a molecular weight in excess of 200kDa, and carbohydrate content of approximately 25%. It circulates in the serum in association with another glycoprotein resulting in a combined MW in excess of 1000kDa. It has been demonstrated immunohistochemically in most types of ovarian cancer but is used to monitor therapy largely in epithelial ovarian carcinoma. The half-life of CA125 is 2 - 6 days.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Specimen Container Paediatric:
Serum (SST or plain tube)
Serum (SST or plain tube)
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Minimum Volume Adult:
1 mL blood
1 mL blood
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Minimum Volume Paediatric:
0.5 mL
0.5 mL
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Sample Stability:
Unseparated: 2 days
Separated:At 20-25C - 3 days
At 2-8C - 5 days
At -20C - 3 months
Unseparated: 2 days
Separated:At 20-25C - 3 days
At 2-8C - 5 days
At -20C - 3 months
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Interpretation:
Refer to NICE CG122 Ovarian cancer: recognition and initial management
https://www.nice.org.uk/guidance/cg122/chapter/Key-priorities-for-implementationRefer to NICE CG122 Ovarian cancer: recognition and initial management
https://www.nice.org.uk/guidance/cg122/chapter/Key-priorities-for-implementation -
Reference Ranges:
Adult: < 35 kU/L
Adult: < 35 kU/L
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Other Info:
lithium heparin plasma sample also acceptable
lithium heparin plasma sample also acceptable
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719Freeman: 0191 244 8889
RVI: 0191 282 9719 -
Routine Email: